Towards organization of care for patients with hereditary haemochromatosis KU Leuven
Hereditary haemochromatosis (HH) is a disorder of iron homeostasis with an autosomal recessive inheritance. The prevalence is 1/200 to 1/400 in Northern Europe and the carrier frequency is 1/10. The penetrance of HH is rather low. Homozygous carriers of the p.C282Y mutation may remain asymptomatic and have a normal quality of life (QoL). But iron accumulation can cause organ damage, resulting in liver dysfunction (fibrosis, cirrhosis, ...