Publications
Cell cycle restriction by histone H2AX limits proliferation of adult neural stem cells Vrije Universiteit Brussel
Adult neural stem cell proliferation is dynamic and has the potential for massive self-renewal yet undergoes limited cell division in vivo. Here, we report an epigenetic mechanism regulating proliferation and self-renewal. The recruitment of the PI3K-related kinase signaling pathway and histone H2AX phosphorylation following GABA(A) receptor activation limits subventricular zone proliferation. As a result, NSC self-renewal and niche size is ...
Sarcoma stratification by combined pH2AX and MAP17 (PDZK1IP1) levels for a better outcome on doxorubicin plus olaparib treatment KU Leuven
Induction of cancer cell stemness by depletion of macrohistone H2A1 in hepatocellular carcinoma KU Leuven
It’s a hoax! The mediating factors of populist climate policy opposition. Vrije Universiteit Brussel
NuA4 and H2A.Z control environmental responses and autotrophic growth in Arabidopsis. Flanders Institute for Biotechnology Ghent University
Determination of genotoxic potencies of pyrrolizidine alkaloids in HepaRG cells using the γH2AX assay Vrije Universiteit Brussel
Pyrrolizidine alkaloids (PAs) are secondary metabolites from plants that have been found in substantial amounts in herbal supplements, infusions and teas. Several PAs cause cancer in animal bioassays, mediated via a genotoxic mode of action, but for the majority of the PAs, carcinogenicity data are lacking. It is assumed in the risk assessment that all PAs have the same potency as riddelliine, which is considered to be one of the most potent ...