Projects
Perturbation of extracellular matrix (ECM)-degrading cellulair devices by means of photoporation-directed nanobody delivery in immune cells and cancer cells. Ghent University
This project will investigate a particular intracellular structure that is found in immune cells, osteoclasts and cancer cells. It consists of many different proteins that together build up a so-called invadopodium. This is a sort of molecular tiny foot or 'drill' that makes holes in the underlying basement membrane. This allows immune cells to engage pathogens that are hidden somewhere in tissues, but also allows cancer cells to escape from ...
Translation of ultra-high performance mixed matrix membrane for gas separations from lab to roll-to-roll production KU Leuven
Highly efficient non-Euclidean optimization and MCMC methods for deep matrix completion KU Leuven
The matrix completion (MC) problem is of interest in many applications, especially in bioinformatics, chemoinformatics, and systems biology. The existing methodologies for dealing with MC problems are based on the linear dependency between the data entries that factorize the matrix into two (or more) low-rank matrices. Moreover, due to the sparsity and scarcity of the entries of the data matrix, MC suffers from unavoidable large ...
Sparse Matrix computational kernels for High Performance Computing KU Leuven
The bottleneck of numerical algorithms on current hardware is the time for memory access, not the time for arithmetic operations. Algorithms for sparse matrices typically have a low arithmetic intensity, this makes that cache reuse and communication hiding is hard. Intel has developed new hardware, named PIUMA (Programmable Integrated Unified Memory Architecture) which consists of many multi-threaded cores, small memory modules and a global ...
Development of Cartilaginous Microtissues based Decellularized Extracellular Matrix for Bone Tissue Engineering KU Leuven
Bone fractures are among the most common traumatic injuries, but regularly heal efficiently by forming a stabilizing cartilage callus that remodels to bone, a process called endochondral ossification (EO). Conversely, critically sized bone defects (exceeding 3 cm) represent a considerable challenge for both patients and orthopedic surgeons. The construction of cartilaginous microtissues presented a developmental bioengineering strategy ...
Matrix metalloproteinases – unravelling the opposing functions in MS. KU Leuven
Matrix metalloproteases (MMPs) are enzymes that play a role in the development of multiple sclerosis. MMPs contribute to an overactive immune system, leading to damage to the central nervous system and impaired nerve cell function. The deleterious effects of MMPs in disease initiation are well known, but recent research seems to indicate that MMPs also play a protective role in central nervous system disorders. The aim of this project is to ...
Development and Application of Novel Filler Based Polymer Supported Mixed Matrix Membranes KU Leuven
My research will focus on the synthesis of the novel Metal-organic framework (MOF) and Deep Eutectic Solvent (DES) for wastewater treatment applications as well as the separation of carbon dioxide (CO2). Iron oxide (Fe2O3) and tetraazaperopyrene (TAPP) based MOFs will be synthesized by using ethanol and dimethylformamide (DMF) as solvents. Porous membranes will be fabricated with Fe2O3/TAPP-based MOF filler for wastewater treatment as the ...
Exploring the Physicochemical Bonding Mechanism in Fibre-reinforced Bitumen-Foamed Aggregate Matrix (FIFA). University of Antwerp
Developing outperforming zeolite-filled mixed matrix membranes to create a viable and sustainable carbon capture KU Leuven
In light of global warming, membrane-based carbon capture has received increasing interest in academia as a viable technology to reduce industrial emission of carbon dioxide (CO2) from power plants and heavy industry. In order to unlock novel markets such as membrane-based carbon capture, new membranes with improved performance (CO2 permeance and CO2/N2 selectivity) are required. In this project, hybrid membranes containing ultrahigh loadings ...