Projects
New insights in the hysteroscopic treatment of intrauterine pathology Ghent University
In this study we look at the treatment of three common abnormalities that can occur on the
inside of the uterus, or womb. These are polyps (i.e. a swelling of the inner lining of the
womb), myomas (i.e. a benign tumor of the muscular wall of the womb) and residual
placental tissue (i.e. a remainder of the afterbirth in the womb). Hysteroscopy is a technique
where a small camera is used to look inside the womb. It has a ...
Development of isogenic human embryonic stem cell-derived 3D neuro-immune cell culture models: pre-clinical evaluation of interleukin 13 for microglia and macrophage immunomodulation under stroke-like pathology. University of Antwerp
Towards a better selection of systemic treatment for patients with ER-positive HER2-negative breast cancer: the use of prognostic and predictive markers in early and metastatic setting KU Leuven
Worldwide, breast cancer represents about 25% of all cancers in women. There is extensive research effort into this highly complex and heterogeneous disease comprising many different histological and molecular subtypes with luminal, oestrogen receptor (ER)-positive human epidermal growth factor receptor 2 (HER2)-negative tumours being the most frequent subtype. Even within this subtype, there is a lot of heterogeneity, which complicates ...
Clinical, pathological and molecular characterization of invasive lobular carcinoma (ILC) KU Leuven
Invasive Lobular Carcinoma (ILC) is the second most common histological subtype of breast cancer (BC) and accounts for up to 15% of all BC. Compared to the most common subtype Invasive Ductal Carcinoma (IDC), ILC differs not only in the clinical presentation of the disease, but also at the histological, morphological, genomic, transcriptomic and immune level. Despite these differences, in clinical practice, the histological subtype is rarely ...
Unraveling carboplatin resistance mechanisms in triple negative breast cancer KU Leuven
Platinum-based chemotherapeutics induce pathological responses in many solid tumors. In breast cancer, their use is common in late metastatic patients. However, there is a growing interest to use carboplatin in (neo)adjuvant therapy regimens for triple negative breast cancer, a subtype characterized by its poor prognosis and limited treatment options. Patients develop resistance to platinum drugs over time, a process that is incompletely ...
The etiology of the aromatase inhibitor-induced musculoskeletal syndrome in breast cancer patients KU Leuven
Scientific and academic cooperation between ICRH / Ghent University and the Hebei Medical University (HMU) China Ghent University
This project involves the provincial regulations for research and knowledge building through international cooperation with strategic foreign regions in
The role of TRP channels in human endometrium in health and disease. KU Leuven
TRP channels form a superfamily of cation channels that can be activated and regulated through strikingly diverse mechanisms, making them suitable candidates for cellular sensors. As such, TRP channels play important roles in various sensory processes such as pain. In addition, TRP channels are also crucially involved in the cellular and systemic homeostasis of calcium and magnesium. Research in the last decade has revealed that dysfunction ...