Key Determinants of Synaptic Excitation/Inhibition Imbalance in Autism Spectrum Disorders - From Genetic Animal Models to Human Patients KU Leuven
Information processing in the brain critically depends on a proper balance between stimulatory (excitatory) and inhibitory signaling at synapses (E/I balance). Neuronal networks in the brain typically maintain an exquisite E/I balance although neural activity varies constantly, but the molecular and cellular mechanisms that allow neurons to maintain stable E/I ratios are largely unknown. Synaptic adhesion molecules, which connect neurons at ...