Projects
EuroGentest2: Genetic testing in Europe - Network for the further development, harmonization, validation and standardization of services. KU Leuven
Impact and viability of a novel mass PCR testing method as a pandemic-fighting strategy KU Leuven
The COVID-19 pandemic has not only affected our health, but also our lifestyles and our economies. Given its high non-symptomatic transmissibility, to stop a pandemic-causing pathogen like SARS-CoV-2 early on its tracks without needing to resort to economy-damaging measures, would have required a mass testing strategy very early on: according to some estimates up to 10% of a nation’s population should have been tested on a daily basis to ...
RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs KU Leuven
The vision of the RISK-HUNT3R consortium is to develop a reliable, efficient and cost-effective chemical safety assessment approach. It will be based entirely on non-animal methods and provide improved protection of the human population against systemic health effects caused by (chronic) chemical exposure. The major innovation provided by RISK-HUNT3R is a complete and truly human-centric risk assessment strategy. RISK-HUNT3R will establish, ...
Erasmus+ Key Action 2 : Genetic counselling in European universities: The case of neurodegenerative diseases - GECONEU Vrije Universiteit Brussel
to healthy individuals who have a family history of disease or patients who may have a disease resulting from a genetic
mutation (Klein, 2020). At-risk relatives of the 30 million Europeans affected by genetic conditions may be neither
recognised nor managed appropriately due to the lack of knowledge about ...
Responsible prediction of gene expression: mitigating genetic risk profiling (PredicGenX). University of Antwerp
Hypergenes. European network for genetic-epidemiological studies: building a method to dissect complex genetic traits, using essential hypertension as a disease model. KU Leuven
Engineering viral vectors for high-throughput CRISPR genetic screens in plants KU Leuven
Tools based on CRISPR-Cas systems hold great potential both for fundamental plant genetics and precision crop breeding. Unlike traditional mutagenic approaches, CRISPR-Cas systems allow for the simultaneous delivery of thousands of unique guide RNAs, enabling the generation of collections of higher-order mutants for rapid functional screens and the discovery of genetic interactions. However, CRISPR technology suffers from a ‘transformation ...
The human genetic and immunological determinants of the clinical manifestations of SARS-CoV-2 infection: Towards personalised medicine KU Leuven
The consequences of SARS-CoV-2 exposure range from a lack of infection to lethal COVID-19. This immense inter-individual clinical variability is the key scientific and medical enigma in the field. While age and certain co-morbidities are known to influence disease outcome, these parameters do not explain all variation. In addition, there are other SARS-CoV-2 phenotypes of clinical importance: multisystem inflammatory syndrome in children and ...
DETECTIVE : Detection of endpoints and biomarkers of repeated dose toxicity using in vitro systems. Vrije Universiteit Brussel
Emphasis was given to systematic ...