Projects
Genetic rescue of the fragile X syndrome in a mouse model. University of Antwerp
Genetic rescue of behavioral alterations in the Nlgn3 R451C mutation mouse model for autism spectrum disorder: Targeting brain excitation/ inhibition imbalance KU Leuven
Development and validation of active and passive immunotherapy targeted at protein Tau in transgenic mouse models for Alzheimer's disease KU Leuven
Inter-relations of protein Tau, GSK3 and Nectin-3 in synaptic structure and plasticity in the hippocampus of mouse models for Alzheimer's disease KU Leuven
Study Of Cooperating Oncogenes In The Development Of T-Cell Acute Lymphoblastic Leukemia Using CRISPR/Cas-Generated Cell And Mouse Models. KU Leuven
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological disease, which arises from the malignant transformation of developing T-cell progenitors. Survival rates are nowadays up to 90% in children and 40% in adults. However, current therapy is associated with many short-term and long-term side effects, and survival rates after relapse or primary resistance remain very low. To address this challenge, current research is ...
Human soft tissue sarcomas xenograft mouse models as an opportunity to improve the therapeutic options for patients. KU Leuven
Belgian Heart Fund: "Exploring the cell-specific mechanisms of aortic disease using fibrillin-1 mutant mouse models" Ghent University
Marfan syndrome is a rare hereditary disorder caused by defects in the fibrillin-1 gene. Patients with Marfan syndrome have a significantly increased risk of developing tissue damage in the aorta, the largest artery in the body that carries the oxygenated blood pumped from the heart. The damage to the aortic wall can cause this blood vessel to rupture, which is an acute life-threatening situation. In our research we aim to understand the ...
Establishment of novel enterovirus mouse models to assess the efficacy of new antivirals and the potential development of drug resistance. KU Leuven
Within the Enterovirus genus (EV, family Picornaviridae), rhinoviruses (RVs) are grouped in three species: RV-A, RV-B and RV-C. For long, these viruses were considered non-harmful pathogens of the human upper respiratory tract. However, RV infections of the lower respiratory tract are increasingly reported. Moreover, these viruses have been associated with severe exacerbations of asthma and chronic obstructive pulmonary ...
Pathogenesis and therapy of the macrophage activation syndrome in virus-induced mouse models. KU Leuven
Hemophagocytic lymphohistiocytosis (HLH) is a rare, hyperinflammatory disease, characterized by an overwhelming cytokine storm and systemic overactivation of immune cells, causing high morbidity and often mortality in children and adults. Two subtypes can be distinguished, primary ‘genetic’ HLH and secondary ‘acquired’ HLH. In contrast to primary HLH, the pathogenesis of secondary HLH remains incompletely understood. Specifically the ...