Projects

1 - 10 of 317 results

Search term:

Genetic profiling of patients with neurodegenerative disease to identify markers for (early) diagnosis and disease progression KU Leuven

Isabelle Cleynen
Department of Human Genetics
Seen the increase in average life expectancy, a dramatic increase in the incidence of age-related neurodegenerative disorders is expected. By the time such a disorder is diagnosed, the brain damage is often extensive, and there may be no hope for treatment that can repair the massive destruction. Effective intervention before overt brain damage, and thus in the early phase of the disease, will be required to optimize patient outcomes. It is ...

Identification of genetic markers for everolimus-resistance in patients with pancreatic neuroendocrine tumors. University of Antwerp

Marc Peeters
Human molecular genetics, Center for Oncological Research (CORE)
Everolimus is a targeted therapy commonly used for patients with advanced pancreatic neuroendocrine tumors (PNETs). Unfortunately, after a while patients develop resistance, seen as progression on medical images. Earlier detection of resistance allows a quicker change to more effective therapies, results in better patient outcome, spares patients from ineffective treatment and reduces costs for society. Building on cell line data, fusion genes ...

Identification of genetic markers for everolimus-resistance in patients with pancreatic neuroendocrine tumors University of Antwerp

Marc Peeters
Center for Oncological Research (CORE), Human molecular genetics, Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO)
Everolimus is a targeted therapy commonly used for patients with advanced pancreatic neuroendocrine tumors (PNETs). Unfortunately, after a while patients develop resistance, seen as progression on medical images. Earlier detection of resistance allows a quicker change to more effective therapies, results in better patient outcome, spares patients from ineffective treatment and reduces costs for society. Building on cell line data, fusion genes ...

Salmonella biofilm formation in chronic carrier pigs: impact on gut colonization, genetic markers for functional diagnostics and potential as target for non-antibiotic therapy KU Leuven

Hans Steenackers
Microbial and Plant Genetics (CMPG)

The goal of this project is to expand the knowledge on the role of Salmonella biofilm in pig farming. In a first subgoal we aim to investigate Salmonella biofilm formation as a strong contributor to its chronic colonization in the pig gut. In a second subgoal we aim to identify genetic markers for the capacity of biofilm formation. These markers can be included in fuctional diagnostic tools that focus on a phenotypic functional feature of ...

Efficiently tracing fraud and illegal fisheries using genetic markers (aimed at food safety and sustainable exploitation). KU Leuven

Filip Volckaert
Ecology, Evolution and Biodiversity Conservation, Laboratory for Cytogenetics and Genome Research
Through the ever increasing demand for fish in combination with systematic overfishing and illegal fisheries, fish stocks are declining worldwide. Nowadays, the deficiencies in wild catch are largely replaced by aquaculture production. However, the aquaculture sector has some major issues with sustainability.
In this project we will develop a forensic tool which can serve as proof for illegal, unreported and unregulated (IUU) products, ...

Predictive genetic markers in gynaecological cancers: how to improve targeted therapy. KU Leuven

Toon Van Gorp
Gynaecological Oncology

The development of more targeted therapies opened up a completely new era in treatment of gynaecological malignancies. However, little is known about the ideal position and timing in the treatment strategy and which patients in particular will benefit from treatments such as poly (ADP-ribose) polymerase inhibitors (PARPi) and immune checkpoint blockade (ICB). The aim of this proposal is to find (epi-)genetic markers that predict response to ...

Predictive genetic markers for targeted therapy in gynaecological malignancies: bridging the gap between “one-size-fits-all” and more personalised treatment approach. KU Leuven

Toon Van Gorp
Laboratory of Translational Genetics (VIB-KU Leuven), Gynaecological Oncology

Recently, more targeted therapies opened up a completely new era in treatment of gynaecological malignancies, which could help to turn around the “one-size-fits-all” approach. Different than the traditional therapies which inhibit cell division of all cells, they inhibit the cancer cell growth by interfering with the cell’s environment. A paradigm shift is created regarding more durable responses with survival benefit and improved quality of ...

Predictive genetic markers for targeted therapy in gynaecological cancers: bridging the gap between “one-size-fits-all” and personalized treatment KU Leuven

Toon Van Gorp
Gynaecological Oncology
Recently, more targeted therapies opened up a completely new era in treatment of gynaecological malignancies, which could help to turn around the “one-size-fits-all” approach. Different than the traditional therapies which inhibit cell division of all cells, they inhibit the cancer cell growth by interfering with the cell’s environment. A paradigm shift is created regarding more durable responses with survival benefit and improved quality of ...

The use of alternative genomic markers to reconstruct the complex evolutionary histroy of neotropical small felids. University of Antwerp

Hannes Svardal
Evolutionary ecology group (EVECO), Systemic Physiological and Ecotoxicological Research (SPHERE)
Tracing the evolutionary origin of species can be a challenging task, especially when these species cross-breed and thereby cloud the genetic record of their evolution. Fast-developing techniques in acquiring genetic information have improved to the point where complete genomes can be routinely sequenced. One of the upcoming questions is how to make optimal use of this massive amount of data. This research project combines the above challenges, ...

Circulating cell-free DNA as an alternative gateway to the genetic features of multiple myeloma and as a surrogate marker for disease burden in multiple myeloma. KU Leuven

Peter Vandenberghe
Department of Human Genetics

This research project explores the research hypothesis that circulating cell-free DNA(ccfDNA) can serve as a minimally-invasive substrate to remotely investigate the genome of the malignant plasma cells in multiple myeloma (MM). We will extensively validate the detection of copy number variations in ccfDNA, by paired analysis of DNA from purified plasma cells by FISH, arrayCGH and low pass sequencing by next-generation sequencing with a ...