Evaluation of the molecular determinants of primary immunodeficiency in adult patients, pathogenesis of STAT1 gain-of-function and evaluation of gene therapeutic approaches. KU Leuven
Primary immunodeficiencies (PIDs) have provided crucial information for the elucidation of immunological pathways. Although many causal mutations in PID patients have been identified, the exact pathogenesis often remains to be elucidated and clues for an individualized therapeutic approach remain absent. In this project we focus on adult patients with a confirmed or suspected primary immunodeficiency. We explore a genetic cause in patients ...