How do microglial cells promote glioma invasion:potential implication of paracrine lipid signaling? KU Leuven
The overarching goal of this proposal is to understand the mechanistic underpinnings of microglia-driven glioma invasion and identify new therapeutic targets that enable a more complete surgical resection to substantially enhance patient survival. Our preliminary results support our proposition that targeting the communication between microglia and glioma cells provides an effective way to block the invasive nature of several GBM subtypes ...