Projects
Characterizing genes and molecular mechanisms involved in frontotemporal lobar degeneration (FTLD) using an integrated approach of molecular genetics and functional genomics. University of Antwerp
Identification of recurrent genetic aberrations in myeloproliferative neoplasms using an integrated genomics approach. KU Leuven
Varieties of Causation in Genetics Ghent University
Classical genetics, molecular genetics and population genetics are the main subdomains of genetics. Each of these subdomains contains many causal claims. These claims belong to different types: classical genetics makes claims about (among others) the effect of genotypes on phenotypes; molecular genetics makes claims about (among others) how the genetic code determines protein synthesis; and population genetics makes claims about (among ...
Genetics and physiology of bimodal protein targeting in yeasts. Studies on the basic mechanisms and possible therapeutic developments. KU Leuven
Cytochrome P450s (CYPs) are proteins that play an enormous role in our life. They synthesize many of our endogenous chemicals, they inactivate most of the drugs we assume (i.e., that’s the reason why the pain killers we take lose potency after a few hours), and also detoxify dangerous pesticides we come frequently in contact with, making our bodies capable of flushing them away CYPs reside mostly in an intracellular organelle called ...
A chemical genetics screen for highly specific inhibitors of nematode feeding site establishment. Ghent University
Plant parasitic nematodes (PPNs) cause about 12% yield loss in agriculture annually, with root-knot nematodes (RKNs) being among the most harmful nematodes. They invade the root and form nematode feeding sites (NFS) in the vascular cylinder by inducing a series of morphological, molecular and biochemical changes in plant root cells, causing severe biotic stress in plants. Moreover, NFS are the sole food source for growth and reproduction of ...
Sabbatical Koen Geuten: Genetics of temperate cereals KU Leuven
My research focuses thematically on biochemistry and genetics of temperate cereal crops.
Until now, we use the model system Brachypodium as a proxy to generate useful knowledge for the crops. However, there is of course an evolution where research directly on the
crops gain in importance. By visiting international top labs/companies in these domains, I want to better define the feasible options for my research group.
In ...
The genetics behind historical socio-demography in Flanders revealed by the human Y-chromosome: an interdisciplinary approach KU Leuven
The male-specific and non-recombining Y-chromosome (chrY) serves as a powerful tool for genetic-genealogy. But, as a chrY-specific sequencing panel did not exist, it has not been linked to a genealogical database yet. During my PhD, I developed the first chrY-specific sequencing panel, the CSYseq, providing a large dataset of 15,813 interesting Y-markers. This CSYseq is useful to determine evolutionary biogeographical ancestry and to identify ...
Improved disease modelling and genetics for inherited platelet disorders KU Leuven
Inherited platelet disorders (IPD) are highly heterogeneous with genetic defects in 63 genes and characterized by a high susceptibility to bleeding and often associated with syndromic features. Many genes have been discovered by whole exome/genome sequencing (WES/WGS) but their exact role in platelet formation and function remains unknown due to the lack of animal or efficient cell-based models. Today, high throughput-sequencing multi-gene ...
Improved disease modelling and genetics for inherited platelet disorders KU Leuven
Inherited platelet disorders (IPD) are highly heterogeneous with genetic defects in 63 genes and characterized by a high susceptibility to bleeding and often associated with syndromic features. Many genes have been discovered by whole exome/genome sequencing (WES/WGS) but their exact role in platelet formation and function remains unknown due to the lack of animal or efficient cell-based models. Today, high throughput-sequencing multi-gene ...