Projects
Selection of driver genes and neuronal differentiation gene modules in neuroblastoma through an integrated genomic analysis Ghent University
Integrative genomic analyses and pathway reconstruction efforts will be implemented to the currently used set of analytical tools as an original and powerful approach to discriminate driver from passenger mutations in the next-generation sequencing of neuroblastoma tumor samples. Gene modules will be obtained and those implicated in normal sympathetic neuronal differentiation will be prioritized for further functional analyses.
Unraveling the genetic etiology of sensory disorders: The role of calcium signaling genes at the auditory inner hair cell ribbon synapse and identification of new genes. University of Antwerp
Dissecting the role of Parkinson's Disease related genes in the regulation of clock neurons and circadian rhythms. KU Leuven
Parkinson’s disease (PD) is a common and incurable neurodegenerative disease. While motor defects and loss of dopaminergic neurons are hallmarks of the disease, alterations in sleep and circadian rhythms are well-recognized common non-motor-related symptoms that precede disease onset and are even thought to be important risk factors. However, a connection between sleep disturbances and the molecular pathogenesis of PD remains elusive. In this ...
Selective resequencing of miRNA genes in neuroblastoma Ghent University
In this project we aim to study the involvement of miRNAs in the development and progression of neuroblastoma. By using next generation sequencing technology to selectively resequence these small non coding genens in a large set of neuroblastoma tumours we will get an in depth view of the mutations possibly occurring in neuroblastoma. This will enhance our insight in this enigmatic disease.
Paget's disease of bone: molecular genetic investigation of the NFkB signaling regulating genes CBL, CBLB, and NR4A1 and functional validation in vitro and in Danio rerio. University of Antwerp
Identification of genes and genetic risk factors for Parkinson's disease. University of Antwerp
Analysis of genes involved in male infertility Vrije Universiteit Brussel
A genomic approach for the identification of genes involved in mental retardation and brain anomalies. KU Leuven
Identification and functional characterization of novel genes causing syndromic microcephaly. KU Leuven
Microcephalie (MC) in humans is a condition characterized by abnormal small head circumference for the respective age and sex. It can occur as isolated feature (non-syndromic forms) or in combination with other characteristics (syndromic forms). MC is genetically heterogeneous, but some of the non-syndromic forms were explained by mutations in genes implicated in cell division and cell cycle progression, including structural genes involved in ...