Projects
Identification of coding and non-coding cancer drivers from whole-genome re-sequencing data using gene regulatory network analysis. KU Leuven
Identification of coding and non-coding cancer drivers using gene regulatory network analysis
Regulation of gene transcription is an essential process, governing complex spatio-temporal expression patterns in every living cell. Gene regulation underlies processes such as the development of embryonic stem cells into various differentiated cell types, or the reprogramming of normal cells into cancer cells. Cancer is characterized by high ...
Identification of a novel gene causing frontotemporal lobar degeneration and amyotrophic lateral sclerosis through whole genome sequencing. University of Antwerp
NXT-EYE: integrated genomics and transcriptomics for gene identification in inherited retinal degeneration Ghent University
Inherited retinal degeneration (RD) is responsible for 5% of blindness worldwide. Genetic
studies have revealed underlying molecular defects in ~50% of individuals with RD, most of
which are located in the coding portion of the genome. The advent of next-generation sequencing (NGS) has revolutionized the genetic landscape. However, the massive amount of
data produced by NGS hampers disease gene identification, requiring ...
Identification and characterization of gene functions involved in synergistic interactions in a pollutant degrading multi-species bacterial consortium. KU Leuven
Gene identification in female patients with intellectual disability and skewed X-inactivation. KU Leuven
Identification of the major determinants that explain intolerance to gene duplication in the flowering plants Ghent University
Genomes are dynamic entities that change over time. An important mechanism by which genomes
evolve novel functions is gene and genome duplication. However, not all cellular processes are
equally malleable by evolution through gene duplication. Studies in human genomes have revealed
that certain genes might be intolerant to duplication, leading to human disease. Similarly, we
recently discovered that many flowering ...
Identification of the gene regulatory networks controlling vascular development in plants – a comparative approach at single-cell resolution Ghent University
When plants colonized the land evolved specialized structures which enabled anchorage and movement of nutrients and water throughout the whole plant, the root and the vascular system. Large evolutionary changes such as this are the result of modifications of the gene regulatory network (GRN), composed of regulators controlling the expression of target genes, that controls organ development. In order to unravel the key changes which led to the ...
Inter-species identification of gene functions in plants based on RNA expression data Seq- Ghent University
The abstract for "Inter-species identification of gene functions in plants based on RNA expression data Seq-" is missing. Please contact the promotor for more information