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De los tiempos turbulentos en los Países Bajos y sobre todo en Gante KU Leuven
'De los tiempos turbulentos en los Países Bajos y sobre todo en Gante' es la crónica que Marcus van Vaernewijck inició en el verano de 1566, cuando algunos predicadores calvinistas consiguieron reunir a centenares de personas para escuchar sus sermones al aire libre. Vaernewijck era un católico convencido, pero se esforzaba por entender y rebatir los argumentos de los calvinistas. Los tres primeros libros de su crónica reflejan el día a día de ...
¿Amo o criado? Carlos V y la sublevación de Gante, 1537-1539. Ghent University
Pourquoi continuer à porter des gants en obstétrique? Ghent University
Targeting the Hedgehog pathway in combination with X‑ray or carbon ion radiation decreases migration of MCF‑7 breast cancer cells Hasselt University KU Leuven
The use of carbon ion therapy for cancer treatment is becoming more widespread due to the advantages of carbon ions compared with X-rays. Breast cancer patients may benefit from these advantages, as the surrounding healthy tissues receive a lower dose, and the increased biological effectiveness of carbon ions can better control radioresistant cancer cells. Accumulating evidence indicates that the Hedgehog (Hh) pathway is linked to the ...
Hedgehog signaling in prostate cancer: Clinical relevance and its potential as a target for radiosensitization KU Leuven
While the Hedgehog (Hh) signaling pathway is essential for numerous processes during embryonic development, its role in adult tissues is more limited. However, there is increasing evidence of uncontrolled reactivation of the Hh signaling pathway in various types of cancer, including prostate cancer (PCa). Emerging data in the literature suggest that the Hh pathway is involved in the development of this disease as well as in the progression to ...
Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened KU Leuven
An essential role for Hedgehog (Hh) signaling in human cancer has been established beyond doubt. At present, targeting Hh signaling has mainly been investigated with SMO inhibitors. Unfortunately, resistance against currently used SMO inhibitors has already been observed in basal cell carcinoma (BCC) patients. Therefore, the use of Hh inhibitors targeting the signaling cascade more downstream of SMO could represent a more promising strategy. ...
Gantries or cantilevers for route guidance on a reorganized arterial road? A before study of route choice effectiveness using a traffic sign simulator (case study) Hasselt University
This study evaluates ex-ante which of two signalization concepts is most effective at a reorganized arterial road in Hasselt (Flanders; Belgium): a gantry (advance direction sign above the road) or a cantilever (advance direction sign alongside the road). Over a distance of 500 meters, three intersections will be replaced by five intersections with traffic lights and the number of sorting lanes will be increased. The complexity of the situation ...