Projects
Hedgehog signaling in prostate cancer: clinical relevance and its potential as a target for radiosensitization KU Leuven
While the Hedgehog (Hh) signaling pathway is essential for numerous processes during embryonic development, its role in adult tissues is more limited. However, there is increasing evidence of uncontrolled reactivation of the Hh signaling pathway in various types of cancer, including prostate cancer (PCa). Emerging data in the literature suggest that the Hh pathway is involved in the development of this disease as well as in the progression to ...
Surface guidance for emerging radiotherapy technologies KU Leuven
Accurate positioning of the patient in the treatment position is of paramount importance for modern radiotherapy, where a highly conformal dose can be delivered to the target volume whilst sparing surrounding healthy tissue. Additionally, detection (and/or compensation) of patient motion during treatment delivery is increasingly required due to the prevalence of high-dose per fraction treatments such as SBRT resulting in a longer fraction ...
Architecture and development of community heritage in post-situations. Strategies for future oriented (socially) sustainable development KU Leuven
Tracing the deep significance of built heritage through encounters with undisclosed protagonists. KU Leuven
This research study is inspired by a great fascination with built heritage, for its tangible beauty, the craftsmanship it holds, and for the meaning generating force of heritage in the past, present and future. It is motivated by a great concern about the future of heritage and its, largely, underestimated present societal role and its irreplaceable importance for a society because it gives rise to cultural and social identity for different ...
Pathofysiological characterization of megakarypoiesis using next generation sequencing KU Leuven
The main function of platelets is to reduce the blood loss after an injury. Platelets originates from MKs in a process called megakaryopoiesis. Defects in megakaryopoiesis can lead to a low platelet count (thrombocytopenia), which can cause severe bleeding problems. Understanding the underlying mechanisms of megakaryopoiesis is crucial to improve medical treatment and identify novel therapeutic targets. This PhD project focused on gaining ...
In Space We Read Trauma: Disclosing Microhistories in Kosovo, 1980-1999 KU Leuven
Trauma Studies, the scholarship analysing representations of disruptive experiences and their effect on identity and memory, is a field largely marked by language-based discourses. In examining the psychological and social factors that influence the comprehension of a traumatic experience, much attention has been paid to how such experience shapes and is shaped by language. However, in the last 25 years, scholars have questioned the tool of ...
The role of spatial memory in urban reconstruction planning after disaster. The Ypres case. KU Leuven
In urban reconstruction planning after a disaster, the pressure on the recovery of space, discourse and organisations brings forward a monomaniac strategy often based on the four-staged recovery model (emergency – restoration – reconstruction – commemoration). Destroyed cities are confronted with a new function: they become a memory landscape, translated by many memorials, monuments and cemeteries. In this way, ...
Automatic multi-sensor validation methods KU Leuven
Collective Spaces in Workers’ Villages in Northeast China: A Critical Socio-spatial Analysis KU Leuven
Workers’ villages were collective housing districts built for industrial employees and their families in the early period of New China. Collective spaces in workers’ villages were a crucial mainstay for the novel socialist life in the 1950s-1970s period. Since 1978 when China launched fundamental reforms nationwide, the once-exclusive workers’ villages have experienced vital changes in many aspects, which have put and are putting pressure on ...