Projects
Functional genomics in human blood platelets. KU Leuven
Drought stress physiology of banana linked to a functional genomics approach. KU Leuven
Functional genomics of Alzheimer disease: Characterization of the risk effect of progranulin missense mutations. University of Antwerp
A functional genomics study in zebrafish to elucidate the role of thyroid hormones and deiodinases in early embryonic development. KU Leuven
A functional genomics study in zebrafish to elucidate the role of thyroid hormones and deiodinases in early emryonic development. University of Antwerp
Unraveling the 17q enigma in neuroblastoma: from functional genomics to molecular therapy Ghent University
Neuroblastoma is a pediatric tumor of the peripheral nervous system. In this study we aim to investigate the role of 17q gain in the oncogenesis of this tumour through (1) the study of integrated genomics of NB, medulloblastoma, tumour initiating cells and normal precursor cells, (2) functional identification of oncogenic 17q miRNAs, (3) analysis of the NB 17q mutome and (4) analysis of chromosome 17 candidate NB genes.
Retinitis pigmentosa: gene discovery and functional analysis through advanced genomics and zebrafish studies Ghent University
The general objective of this project is disease gene discovery in sporadic or autosomal recessive retinitis pigmentosa (RP). Specific objectives are: (1) prescreening of all known RP genes using next-generation sequencing (NGS); (2) identification of new disease genes through homozygosity mapping and NGS of candidate regions; (3) in vivo functional analysis of newly identified RP genes in zebrafish.
Single-cell DNA and RNA sequencing of human cleavage and blastocyst stage embryos to study genomic instability and its functional impact on early development KU Leuven
The human genome is considered stable throughout development. However, recent analyses of human single cells –particularly of human preimplantation embryos following in vitro fertilization as well as of normal human primary tissue– challenge this dogma. Amazingly little is known about the true rate at which somatic DNA-mutation occurs, the different natures of the acquired mutations, as well as the cellular responses and selection processes ...