ZAP post in functional genomics and genomic bio-computing Ghent University
ZAP post in functional genomics and genomic bio-computing (Jo Vandesompele)
ZAP post in functional genomics and genomic bio-computing (Jo Vandesompele)
This proposal deals with personalized functional genomics in Mendelian disorders. We will tackle non-‐coding variation by NGS approaches. We will use state-‐of-‐the-‐art knockdown, knockout and
rescue experiments in model organisms. Furthermore, functional assays in patient-‐derived cellular models such as hiPSCs will lead to understanding of mutations and mechanisms.
In addition, we will optimize PGD-‐NGS. ...
The focus of my proposed research is on the ecology of emerging zoonotic viruses, both in their natural and dead-end host context. I propose to investigate these viruses’ clinical relevance for and the genetic susceptibility of their host, and to explore and predict the mechanisms that determine the capability of these reservoir-borne viruses to switch hosts as well as their pathogenic potential. To achieve these goals, I am finalizing an ...
BOF-ZAP-ambt in Bioinformatics, functional genomics, RNA-biology, oncology (Pieter Mestdagh)
Neuroblastoma is a pediatric tumor of the peripheral nervous system. In this study we aim to investigate the role of 17q gain in the oncogenesis of this tumour through (1) the study of integrated genomics of NB, medulloblastoma, tumour initiating cells and normal precursor cells, (2) functional identification of oncogenic 17q miRNAs, (3) analysis of the NB 17q mutome and (4) analysis of chromosome 17 candidate NB genes.
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The general objective of this project is disease gene discovery in sporadic or autosomal recessive retinitis pigmentosa (RP). Specific objectives are: (1) prescreening of all known RP genes using next-generation sequencing (NGS); (2) identification of new disease genes through homozygosity mapping and NGS of candidate regions; (3) in vivo functional analysis of newly identified RP genes in zebrafish.