Data-driven 3D Traction Force Microscopy to unravel microvascular disease mechanisms. KU Leuven
The mechanical interactions between cells and the extracellular matrix (ECM) play a crucial role in many diseases. One such disease is Cerebral Cavernous Malformations (CCM) that is caused by mutations in ccm1-3 genes leading to upregulation of actomyosin contractility and increased remodeling of ECM fibers. Given this importance of cell-matrix mechanics for a better understanding of disease progression, there is a strong need for in vitro ...