Multicenter validation trial of [18F]AlF-FAPI-74 for PET imaging of cancer-associated fibroblasts through fibroblast activation protein inhibitors (FAPI) in digestive tumors KU Leuven
This project will study in the diagnostic accuracy of a novel positron emission tomography (PET) tracer ([18F]AlF-FAPI74) targeting fibroblast activation protein (FAP) in a prospective, non-randomized, multicenter, multi-cohort, interventional phase II/III trial. FAP is a promising emerging molecular target, expressed on cancer-associated fibroblasts and is independent of cancer cell characteristics such as tumoral glycolytic phenotype and ...