Funtionalised Azabicycloalkanes as conformational restricted Skeletons for structural Analogues of physiological active compounds Ghent University
The cyanide induced dynamic intramolecular cyclization will be further developed for the synthesis of new azabicyclic skeletons which are important in agrochemistry and pharmaceutical industry. During this study, the attention will be focussed on the synthesis of new 2,4-methanoproline analogues (anti-feedant) as well as tricyclic methanoproline analogues and the syntesis of epibatidine analogues (analgesic activity).
Conductive stimuli-responsive polymer nanocomposites for damage sensing and active healing in autonomous self-healing soft robotic systems Vrije Universiteit Brussel
Inherited predisposition for breast cancer in the next generation sequencing era: evaluation of the role of genes involved in homologous recombination and G2/M checkpoint control and decelopment of a functional assay. Ghent University
In less than 20% of the familial breast cancers a germline mutation in the major breast cancer genes BRCA involved in hte same pathway by a next generation sequencing approach. Furthermore, we will develop a functional assay to elucidate the role of variants of unknown significance.
Relation between residual beta cell function and glycemic variability in (pre)type 1 diabetes. KU Leuven
Investigation of supramolecular nanostructures in liquid state using diffusion ordered (DOSY) NMR Vrije Universiteit Brussel
The role of the GATA transcription factors in the development and function of mast cells in asthma. Ghent University
A conditional GATA knock-out will be induced in mastcells by using Cre/loxP technology. In vitro experiments will define the expression pattern of Gata-genes en their regulators during development of mast cells and the effect og gata-deficiency on the development and funtion of mastcells. In vivoo experiments will define the effects of GATA-deficiency in a mousemodel of asthma.
Paracrine and transcriptional regulation of renewal and differentiation of embryonic and adult multi-potent progenitor cells in vertebrates KU Leuven
Virulence factors of Bacillus cereus and host-pathogen interactions Ghent University
Bacillus cereus is one of the key toxigenic foodborne pathogens of concern to modern food industry,
especially for a group of refrigerated foods of extended durability and dry foods. This species
comprises a highly versatile, psychrotrophic and mesophilic, and incredibly armored group of
opportunistic pathogenic bacteria, which directly in the food or once ingested by the human host
may secrete a wide array of harmful ...