Projects
Development of a cell motility gene expression signature to confront with the gene expression profile of inflammatory breast carcinoma. University of Antwerp
Gene expression profiles as biomarkers in human biomonitoring: the study of temporal variation in gene expression and relationships with exposure and effects of environmental pollution Ghent University
As part of a preventive environment and health, there is a strong need for the development of new biomarkers of exposure and / or effects of environmental pollutants, which already give an indication of possible health effects at an early stage. Measuring gene expression in peripheral blood using microarray is an attractive concept. The underlying hypothesis is that circulating blood reflects the physiological response of an organism, and ...
Objectifying Assessment of Human Emotional Processing and Expression of Clinical and Psychotherapy Applications (EMO-App) Vrije Universiteit Brussel
Differential expression and secretion of microRNAs by specific cardiac fibroblast phenotypes KU Leuven
The heart is composed of many cells types, out of which cardiac myocytes and fibroblasts form the majority. Cardiac myocytes are the muscle cells, which are responsible for the rhythmic beating of the heart. Fibroblasts produce proteins which maintain the architecture of the heart. However, after heart attack whereby muscle cells are lost (infarction), fibroblasts modify themselves to become myofibroblasts. These cells produce collagen that ...
Development of virus-specific anti-NS1 antibodies and expression system for flavivirus recombinant NS1 for use in neurotropic flavivirus diagnostic, therapeutics, and vaccination development (Flavivirus_NS1_project). University of Antwerp
Unraveling how ZEB1 expression in conventional type I dendritic cells regulates the presence of other cell types specifically in the spleen and the functional consequences of this regulation. Ghent University
Conventional dendritic cells (cDCs) exist as cDC1s and cDC2s and develop from precursors through the concerted action of distinct transcription factors (TFs). Recently, the ZEB family of TFs have been added to the list of TFs mediating cDC development as we and others, have shown that ZEB2 regulates the decision to become a cDC2. Additionally, our data also suggest that its homolog, ZEB1, is a critical cDC TF, specifically regulating splenic ...
Tackling functionality and balanced expression of cytochrome P450 enzymes: a generic toolbox for the production of specialized plant metabolites in bacteria Ghent University
The natural diversity of plant metabolites, such as flavonoids, offers a plethora of attractive attributes through the decoration of a common skeleton. Oxygenation is the most common decoration and is added in the final biochemical steps in the plant endoplasmic reticulum. Industrial production of these specialized flavonoids can be achieved chemically, through plant cell cultures or via extraction. These routes are paired with high costs and ...
Tackling functionality and balanced expression of cytochrome P450 enzymes: a generic toolbox for the production of specialized plant metabolites in bacteria Ghent University
The natural diversity of plant metabolites, such as flavonoids, offers a plethora of attractive attributes through the decoration of a common skeleton. Oxygenation is the most commondecoration and is added in the final biochemical steps in the plant endoplasmic reticulum. Industrial production of these specialized flavonoids can be achieved chemically, through plant cell cultures or via extraction. These routes are paired with high costs and ...
Dissecting the dependence of liver metastases on the hypoxia-induced expression of nutrient transporters. KU Leuven
Metastasis is the leading cause of death in cancer patients with the liver being the site of ~25% of all cases. Liver metastases are involved in nearly twice as many deaths (1.65 million/year) as primary liver cancer. The most prevalent cancer metastasizing to the liver is breast cancer (BC). Unfortunately, we currently lack therapies that can prevent and treat BC-derived liver metastases. Solute carrier (SLC) transporters are a crucial link ...