Structure and folding of XNA aptamers studied by computational and experimental methods KU Leuven
Aptamers are folded oligonucleotides that bind to a specific target with a high affinity and selectivity. Originally they were composed of natural nucleic acids (RNA or DNA) that are identified in a large library through a process termed Systematic Evolution of Ligands by EXponential enrichment (SELEX). Since natural nucleic acids have short half-life in biological conditions, research shifted to aptamers composed of artificial (xeno) nucleic ...