Improving detection of drug-resistant tuberculosis (TB by use of novel phenotypic and genotypic tests Institute of Tropical Medicine
Francis Varraine, Leen Rigouts, Bouke de Jong
In 2011 the estimates of new cases of TB were 8.7 million, with 1.4 million deaths from TB, 1 million in non- HIV patients and 430 000 in co-infected patients. Multidrug resistant tuberculosis (MDR-TB), resistance to the two most powerful anti-TB drugs, INH and RMP, is recognized as a global epidemic. When this resistance pattern is combined with resistance to fluoroquinolones (such as ofloxacin or moxifloxacin) and to injectable second-line ...