Publications
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Epigenetics in toxicology: the implications of epigenetic alterations driven by external exposures for human health Vrije Universiteit Brussel
The prospect that non-genotoxic environmental exposures of physical, chemical or social nature act on epigenetic mechanisms opens a new emerging field in toxicology. Epigenetics refers to the stable changes in gene expression programming that could alter the phenotype in absence of a change in DNA sequence. Epigenetic modifications, which include amongst others DNA methylation, covalent modifications of histone tails, and regulation by ...
Comprehensive histone epigenetics : a mass spectrometry based screening assay to measure epigenetic toxicity Ghent University
Evidence of the involvement of epigenetics in pathologies such as cancer, diabetes, and neurodegeneration has increased global interest in epigenetic modifications. For nearly thirty years, it has been known that cancer cells exhibit abnormal DNA methylation patterns. In contrast, the large-scale analysis of histone post-translational modifications (hPTMs) has lagged behind because classically, histone modification analysis has relied on site ...
Inherited memories : the role of epigenetics in intergenerational resistance against nematodes in rice Ghent University
Epigenetics and transgenerational effects of toxic stress in the water flea Daphnia magna Ghent University
Epigenetics is the study of mitotically or meiotically heritable changes in gene function that occur without a change in the DNA sequence. Epigenetic changes can be triggered by environmental factors and associated changes in gene expression often lead to phenotypic modifications. Epigenetic alterations can sometimes be transferred to subsequent generations, even when the external factor which induced the epigenetic change is no longer present ...