Projects
EVZYM: A new source of native human targets in high throughput screening (HTS) of enzyme inhibitors – TMPRSS2 as an example. University of Antwerp
Clinical development of Enzyme Replacement Therapy in alpha-Mannosidosis patients using recombinant human enzyme. KU Leuven
Optimising the enzyme discovery pathway through omics and AI KU Leuven
The PhD project is part of the intercluster project Enzymares that seeks to speed up enzyme discovery by developing an enzyme prediction toolbox. The toolbox will optimise the enzyme discovery pathway through: 1. an improved high-quality database that integrates different types of molecular and biological data 2. the inclusion of ecological information about the organism and its habitat, as organisms inhabiting extreme habitats are far more ...
Enzyme functionality during the baking phase of bread making KU Leuven
Enzymes are used in a wide array of applications, including cereal-based food systems. It is therefore not surprising that the global demand for enzymes is growing rapidly. In addition, there is a constant hunt for new and/or better performing enzymes in terms of substrate selectivity, inhibition sensitivity, chiral selectivity, and tolerance against extreme pH and temperature conditions. In order to obtain sufficient bread quality, yeast has ...
Enzyme biodiscovery pipeline optimisation via toolbox development Ghent University
The OVERALL OBJECTIVE of ENZYMARES is to optimize the enzyme discovery pathway, with a specific focus on three stages of the pathway: (1) data collection, (2) algorithm and (3) process performance. -At the input level, the goal of ENZYMARES is to leverage on the unique functional characteristics of biological resources from (marine) habitats to discover enzymes that can contribute to faster and more efficient industrial processes. -At the ...
Enzyme biodiscovery pipeline optimisation via toolbox development Catalisti
The OVERALL OBJECTIVE of ENZYMARES is to optimize the enzyme discovery pathway, with a specific focus on three stages of the pathway: (1) data collection, (2) algorithm and (3) process performance. -At the input level, the goal of ENZYMARES is to leverage on the unique functional characteristics of biological resources from (marine) habitats to discover enzymes that can contribute to faster and more efficient industrial processes. -At the ...
Towards more effective enzyme replacement therapy for inherited and acquired Lysosomal Storage Diseases of muscle tissue. Ghent University
Breakdown of waste compounds in our cells is essential for their long-term viability. However,
when people have a mutation in a gene that code for an enzyme that facilitates the degradation
process or when people age, waste products are not removed very efficient anymore. One group
of such diseases is called Lysosomal Storage Diseases (LSD). This results in an accumulation of
these waste compounds in the lysosomes of ...
Enzyme prediction toolbox KU Leuven
Enzymes are used in various industrial sectors (chemistry, food, (aqua-)feed, agriculture, cosmetics, pharmaceuticals, neutraceuticals). The current available supply is nevertheless limited, and there is a high demand for new, better and more versatile enzymes. The potential of alternative (including marine) enzymes is hardly explored because it costs a lot of time and money for the industry. The EnzyMares project now wants to focus on ...
Application of enzyme substrate analogues: from inhibitors with anti-mycobacterial properties to synthetic genetic polymers KU Leuven
Part 1:
Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium tuberculosis (M. tuberculosis).It is regarded as the leading cause of death from a single infectious agent, even above HIV/AIDS. Although the global tuberculosis incidence has declined marginally over the past two decades, it still affects 10 million people each year and remains out of control in several parts of Africa ...