Sex hormone binding globulin in men: the free hormone hypothesis revisited during aging and endocrine disorders KU Leuven
Sex hormones (with testosterone as main male sex hormone) belong to the family of steroid hormones. Only the ‘free’ (unbound) fraction is active, but in the circulation these hormones are mainly bound to proteins, with sex hormone binding globulin (SHBG) as most important player. Concentrations of SHBG and thus biological availability of sex steroids change considerably, not only during disease but also during aging. Moreover, the assessment ...