Projects
Moving Heart Failure Forward: from understanding exercise intolerance in heart failure patients, to an individualized rehabilitation prescription to improve the treatment of the disease. Ghent University
Chronic heart failure represents a fundamental health and financial challenge for Flanders and European society. While physical exercise represents a key rehabilitation strategy, up to 50% of patients have been characterized as nonresponders by previous studies for reasons that are still unclear. In this context, research focused for a long time on the central limitations (the heart) as the cause of exercise intolerance in these patients, but ...
Every cell counts! Transforming exercise science through single fiber transcriptome analysis in human skeletal muscle Ghent University
Public health initiatives promoting physical activity and exercise are important to prevent and treat chronic diseases. In order to understand the underlying mechanism, we have to realize that ‘every cell counts’ in the diversity of ways the human body adapts to exercise. This is especially true for skeletal muscle, which is the main target organ for adaptations to benefit health and performance. The current project aims to expand muscle ...
Beneficial effects of cannabidiol on muscle recovery, sleep and exercise performance in athletes; beyond the hype KU Leuven
Cannabidiol (CBD), a non-intoxicating cannabinoid, has been reported to exert a number of physiological, biochemical and psychological effects which might be beneficial for athletes. Anecdotal evidence indicates that the supplement becomes increasingly popular amongst recreational and professional athletes. However, most evidence is based on animal studies and on clinical trials in patient populations. Intervention studies in athlete ...
The FiREwORK trial - self-management with FootweaR combined with Exercise for OsteoaRthritis (OA) at the Knee: a phase II randomized controlled trial Ghent University
Knee OA is an important cause of disability worldwide. No effective cure exists and many patients
will eventually undergo costly joint replacement. Clinical guidelines emphasize that non-drug nonsurgical
treatment should constitute first-line treatment. Exercise therapy is strongly recommended
for knee OA. However, overall treatment effects on symptoms are modest at best, which is further
...
Tackling FRAILTY: ACTIVE-AGE@home: a home-based functional exercise program for community dwelling frail older adults Odisee vzw
EXercise and the GUT in liver and kidney Transplant recipients [EXGUTT] Ghent University
Although liver and kidney transplantation allowed for tremendous improvement in overall recipient survival, cardiovascular disease has emerged as a leading cause of death in this population. Poor physical fitness, only recovering slowly and incompletely after transplantation, adds to the heightened cardiovascular risk of hypertension, diabetes, dyslipidemia and obesity in these patients. The gut microbiome has emerged has a modulator of ...
Modern pain neuroscience applied to pain in breast cancer survivors: a randomized clinical trial of pain neuroscience education combined with exercise therapy. Vrije Universiteit Brussel
During survivorship, surveillance for recurrence is a top priority.
However, health caretakers and patients are at risk of neglecting other aspects of their health status such as pain that can have a big impact on the health-related quality of life (HRQoL) and healthcare costs. One out of three breast cancer survivors (BCS) will face pain complaints long after ...
Individualized exercise prescription: muscle typology dictates optimal training modalities Ghent University
There are considerable differences among individuals in the magnitude of improvement in
cardiorespiratory fitness in response to a standardized exercise program. Understanding why there
is human variability in the adaptations to training is of particular importance for personalized
exercise medicine applications and also for elite athletes motivated by the pursuit of sports
performance. The large inter-individual ...
Role of Ketone bodies in muscle anabolism and catabolism during exercise and training KU Leuven
Ketone bodies are molecules present in minimal amounts in blood under physiological conditions. Their increment is associated with fasting and high-fat diet. Ketone bodies can replace glucose as an energy source in muscle and brain. Since for skeletal muscle their utilization can provide a readily available alternative to glucose, we hypothesize that ketone bodies administration can stimulate metabolic reprogramming of muscles. However this ...