Patient Derived Xenograft Platform Ghent (PDXGhent) Ghent University
Patient-derived xenograft models (PDX), in which tumor fragments surgically dissected from cancer patients are directly transplanted into immunodeficient mice, retain the principal histologic and genetic characteristics of their donor tumor and remain stable across earliest passages. Based on this, PDX models are considered superior preclinical cancer models that offer predictive insight into clinical outcomes. As such they are widely used for preclinical drug evaluation, biomarker identification, biologic studies, and personalized medicine strategies.
The UGent expertise and ...