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Study of determinants in the immune escape of melanoma and identification of possible strategies to reverse this escape. Ghent University
Melanoma is a very immunogenic tumor. Clinical responses are despite immunotherapeutic interventions limited and currently responders can't be identified in advance.
This project will focus on the detection of myeloid suppressor cells (MSC) and regulatory T-cells (Tregs) in melanoma patients. Likewise the tumoral expression of immunomodulating proteins will be determined.
Evaluating the Role of Autophagy in the Tumor Vasculature and as Anti-angiogenic Escape Mechanism KU Leuven
Escape the past: A cue to forget emotional memories KU Leuven
Understanding non-genetic processes remodelling the tumor ecosystem, cancer cell death and immune escape mechanisms KU Leuven
Efficient tumor clearance by anticancer therapies requires effective therapy-mediated debulking along with the engagement of the immune system. The induction of regulated cancer cell death (RCD) able to reinstate, rather than suppressing, anticancer immune responses -so called immunogenic cell death - is therefore a highly desirable therapeutic effect. However, the recognition and clearance of residual cancer cells by the immune system, ...