Projects

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HavePhAIth: Human Phage therapy using AI to design phage cocktails against ESKAPE pathogens KU Leuven

Rob Lavigne
Animal and Human Health Engineering (A2H), Microbial and Plant Genetics (CMPG)
Human Phage Therapy (PT) is a promising route for the treatment of increasingly drug-resistant bacterial infections. Belgium is leading the implementation of PT in Europe, and the technique is currently in operations at the Queen Astrid Military Hospital (QAMH), and was recently implemented at UZ Leuven. Indeed, a Multidisciplinary Phage Task Force (MPTF) has been set up within UZ Leuven to provide PT to patients with difficult-to-treat ...

Study of determinants in the immune escape of melanoma and identification of possible strategies to reverse this escape. Ghent University

Lieve Brochez
Department of Dermatology

Melanoma is a very immunogenic tumor. Clinical responses are despite immunotherapeutic interventions limited and currently responders can't be identified in advance.

This project will focus on the detection of myeloid suppressor cells (MSC) and regulatory T-cells (Tregs) in melanoma patients. Likewise the tumoral expression of immunomodulating proteins will be determined.

Evaluating the Role of Autophagy in the Tumor Vasculature and as Anti-angiogenic Escape Mechanism KU Leuven

Gabriele Bergers
Laboratory for Tumor Microenvironment and Therapeutic Resistance (VIB-KU Leuven), Laboratory of Cell Death Research & Therapy (VIB-KU Leuven), Translational Cell & Tissue Research, Research Group Experimental Neurosurgery and Neuroanatomy
Autophagy is a major degradative pathway in the cell, implicated in cellular homeostasis and stress responses. Numerous studies have demonstrated that cancer cells pirate autophagic pathways for survival in the harsh tumor environment. As such, there is a growing interest in inhibiting autophagy as a potential anti-cancer therapy. However, the rational for targeting autophagy stems from cell-autonomous effects as a tumor cell survival pathway. ...

Escape the past: A cue to forget emotional memories KU Leuven

Tom Beckers
Centre for Psychology of Learning and Experimental Psychopathology
Directed forgetting manipulations have been repeatedly applied in declarative memory research to investigate intentional, instructed forgetting. We recently developed a novel directed forgetting fear conditioning procedure aimed at examining instructed forgetting of emotional, rather than declarative memories. In a series of studies, we observed a clear memory deficit for items that were instructed to be forgotten, as well as an attenuation of ...

Understanding non-genetic processes remodelling the tumor ecosystem, cancer cell death and immune escape mechanisms KU Leuven

Patrizia Agostinis
Laboratory of Cell Death Research & Therapy (VIB-KU Leuven)

Efficient tumor clearance by anticancer therapies requires effective therapy-mediated debulking along with the engagement of the immune system. The induction of regulated cancer cell death (RCD) able to reinstate, rather than suppressing, anticancer immune responses -so called immunogenic cell death - is therefore a highly desirable therapeutic effect. However, the recognition and clearance of residual cancer cells by the immune system, ...

The fifth estate or an echo chamber of the fourth estate? The impact of social media on sourcing practices and agenda-setting in journalism. University of Antwerp

Steve Paulussen
Media, Movements and Politics (M2P), Antwerp Media in Society Centre (AMSoC)
The aim of this PhD research project is to investigate to what extent and how social media are reshaping sourcing and agenda-setting practices in mainstream journalism and how this affects the mediated debate on public affairs. To this end, a three-step multi-method research design is proposed, which will generate statistical evidence and in-depth insights into the role of social media in the flow of news in today's networked public sphere. ...

SRP-Onderzoekszwaartepunt: Strategic Research Programme on media economics: Algorithm-Driven Media industries and how they reshape value in small markets Vrije Universiteit Brussel

Pieter Ballon
Communication Sciences
In the context of on-demand distribution and consumption of media content, online delivery platforms rely on a relatively new component in media industries: algorithms. In practice, algorithms facilitate the online curation of large on-demand catalogues (e.g., for streaming services such as Netflix or video-sharing platforms such as YouTube), and, by analysing user data, they offer personalised recommendations for content (e.g., news ...

Real estate developments in and around regional airports. University of Antwerp

Wouter Dewulf
Transport and Regional Economics
Regional airports face a viability problem due to the imbalance between the socio-economic role they fulfil and their negative profit and loss statement. Therefore, the primary objective of this research is to determine whether real estate developments in and around regional airports can increase this (currently negative) profit and loss statement without proportionally increasing the social costs. To achieve this, four research questions were ...

Sustainable real estate development: towards a new concept of ownership KU Leuven

Dorothy Gruyaert
Faculty of Law and Criminology, Kulak Kortrijk Campus
The research concerns the question how the law can contribute to a sustainable real estate development. Both private and public actors must firmly commit to a transition in real estate focusing on the needs of the present generation, in terms of affordable and high-quality housing, without however jeopardizing the future generations. This necessary transition to sustainability is twofold and affects our concept of ownership. The first transition ...

The effect of energy performance certificates on real estate prices, investments in energy efficiency and energy consumption. University of Antwerp

Sven Damen
Accountancy and Finance
Mandatory energy performance certification for buildings is increasingly used in many countries. Energy performance certificates (EPCs) are seen as a key instrument to increase awareness of energy efficiency, which may affect real estate prices, investments in energy efficiency and ultimately energy consumption. Despite the widespread use and substantial administrative costs to implement, empirical evidence on whether or not mandatory ...