Projects

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'Exploring the non-genetic (i.e. ePIgenetic) mechanisms that contribute to therapy Escape in melanoma — EscaPI - Marie curie individual fellowship Aurélie Boussard Flanders Institute for Biotechnology

Marine Jean Christophe
Marine Lab
Analysing pathways that underlie the genesis, progression and maintenance of cancer, understanding how the genes that are implicated in cancer control fundamental cellular processes in normal cells, understand the mechanisms by which non-mutational (i.e. epigenetic and post-transcriptional) events interfere with these natural processes to bring about tumour development and to affect therapy outcome, research on concept of aberrant RNA biology in ...

HavePhAIth: Human Phage therapy using AI to design phage cocktails against ESKAPE pathogens KU Leuven

Rob Lavigne
Animal and Human Health Engineering (A2H), Microbial and Plant Genetics (CMPG)
Human Phage Therapy (PT) is a promising route for the treatment of increasingly drug-resistant bacterial infections. Belgium is leading the implementation of PT in Europe, and the technique is currently in operations at the Queen Astrid Military Hospital (QAMH), and was recently implemented at UZ Leuven. Indeed, a Multidisciplinary Phage Task Force (MPTF) has been set up within UZ Leuven to provide PT to patients with difficult-to-treat ...

HavePhAIth: Human phage therapy against the ESKAPE pathogens using AI KU Leuven

Rob Lavigne
Animal and Human Health Engineering (A2H)

Human Phage Therapy (PT) is a promising route for the treatment of drug-resistant bacterial infections. Belgium is currently leading the implementation of PT in Europe, and the technique is currently in operations at the Queen Astrid Military Hospital (QAMH) and at UZ Leuven. A Multidisciplinary Phage Task Force (MPTF) has been set up within UZ Leuven to provide a PT framework for patients with difficult-to-treat infections. However, the ...

Study of determinants in the immune escape of melanoma and identification of possible strategies to reverse this escape. Ghent University

Lieve Brochez
Department of Dermatology

Melanoma is a very immunogenic tumor. Clinical responses are despite immunotherapeutic interventions limited and currently responders can't be identified in advance.

This project will focus on the detection of myeloid suppressor cells (MSC) and regulatory T-cells (Tregs) in melanoma patients. Likewise the tumoral expression of immunomodulating proteins will be determined.

ILS 2022: Crypto escape room Vrije Universiteit Brussel

An Braeken
Mathematics, Engineering Technology, Digital Mathematics
In this project we will build an escape room, where several of the riddles
can be solved using classical cryptosystems (Caesar cipher, scytale,
cryptex, simple watermarking system,…). A brief description of this crypto
systems will be made available so that participants can (largely)
be able to perform independently. After finding the ultimate code, the safe can be opened
from which one 3D-printed bitcoin can then be ...

Would mayors rule a better world? An analysis of how city networks can escape gridlock in the climate mitigation field KU Leuven

Ben Derudder
Public Governance Institute

The Paris Climate Agreement formally recognizes the role of local governments/cities in combating global warming. Cities have in fact been collaborating on climate change in international city networks for a long time, with these networks often being hailed as a promising alternative or addition to gridlocked interstate cooperation. However, it remains insufficiently clear how local governments succeed in avoiding or escaping the structural ...

Evaluating the Role of Autophagy in the Tumor Vasculature and as Anti-angiogenic Escape Mechanism KU Leuven

Gabriele Bergers
Laboratory for Tumor Microenvironment and Therapeutic Resistance (VIB-KU Leuven), Laboratory of Cell Death Research & Therapy (VIB-KU Leuven), Translational Cell & Tissue Research, Research Group Experimental Neurosurgery and Neuroanatomy
Autophagy is a major degradative pathway in the cell, implicated in cellular homeostasis and stress responses. Numerous studies have demonstrated that cancer cells pirate autophagic pathways for survival in the harsh tumor environment. As such, there is a growing interest in inhibiting autophagy as a potential anti-cancer therapy. However, the rational for targeting autophagy stems from cell-autonomous effects as a tumor cell survival pathway. ...

Escape the past: A cue to forget emotional memories KU Leuven

Tom Beckers
Centre for Psychology of Learning and Experimental Psychopathology

Emotional memories are at the root of anxiety-related disorders, yet current interventions aimed at modifying such memories suffer from a lack of long-lasting, persistent effects, allowing for the gradual return of anxiety complaints. This highlights the need for novel methods to manipulate emotional memories, to help people forget burdensome events. Directed forgetting manipulations have been repeatedly applied in declarative memory research ...

Escape the past: A cue to forget emotional memories KU Leuven

Tom Beckers
Centre for Psychology of Learning and Experimental Psychopathology
Directed forgetting manipulations have been repeatedly applied in declarative memory research to investigate intentional, instructed forgetting. We recently developed a novel directed forgetting fear conditioning procedure aimed at examining instructed forgetting of emotional, rather than declarative memories. In a series of studies, we observed a clear memory deficit for items that were instructed to be forgotten, as well as an attenuation of ...

A new mechanism of tumor escape from innate-like T lymphocytes Ghent University

Georges Leclercq
Department of Diagnostic Sciences, Department of Clinical chemistry, microbiology and immunology

Professor Leclercq and his team studied certain mechanisms at the basis of the multiplication of cancer cells and metastasis (or metastases). They study, in particular, a protein that is produced by tumors (neoplasms) and which can interfere with the proper functioning of the natural defense mechanism of the body. Tumor cells have developed several mechanisms that promote cell proliferation and metastases to other organs or to avoid being ...