Appearance of a Single Amino Acid Insertion at Position 33 in HIV Type 1 Protease Under a Lopinavir-Containing Regimen, Associated with Reduced Protease Inhibitor Susceptibility KU Leuven
HIV drug resistance is a multifactorial phenomenon and constitutes a major concern as it results in therapy failure. The aim of this study was to assess the impact of an amino acid insertion identified at position 33 of the protease gene, derived from samples from three patients under lopinavir therapy, on viral fitness and protease inhibitor (PI) resistance. Successive samples were available from one of the patients for genotypic and phenotypic ...