DE ROL VAN HET ENDOTHEEL IN MUCOVISCIDOSE GEASSOCIEERDE LEVERZIEKTE KU Leuven
Cystic fibrosis (CF) is an autosomal recessive disorder most frequently observed in the Caucasian population with an annual incidence of 1 in 3000 live births. CF is a multisystem disease primordially affecting the lungs but also the pancreas, intestines, liver, vas deferens and sweat glands. It results from loss of function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The CFTR gene encodes a chloride ...