Publications
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Emerging infectious diseases [letter] Institute of Tropical Medicine
Population age and household structures shape transmission dynamics of emerging infectious diseases University of Antwerp Hasselt University KU Leuven
Host population demographics and patterns of host-to-host interactions are important drivers of heterogeneity in infectious disease transmission. To improve our understanding of how population structures and changes therein influence disease transmission dynamics at the individual and population level, we model a dynamic age- and household-structured population using longitudinal microdata drawn from Belgian census and population registers. At ...
Bacterial extracellular vesicles : an emerging avenue to tackle diseases Ghent University Flanders Institute for Biotechnology
A growing body of research, especially in recent years, has shown that bacterial extracellular vesicles (bEVs) are one of the key underlying mechanisms behind the pathogenesis of various diseases like pulmonary fibrosis, sepsis, systemic bone loss, and Alzheimer's disease. Given these new insights, bEVs are proposed as an emerging vehicle that can be used as a diagnostic tool or to tackle diseases when used as a therapeutic target. To further ...
Preparing clinicians for (re-) emerging arbovirus infectious diseases in Europe University of Antwerp
Background: Arthropod-borne virus (Arbovirus) infections are considered an emerging threat for Europe, with an increase in cases in recent decades. The increase in global travel and trade has contributed to the introduction of vectors and viruses into new geographical areas. Tropical arboviruses such as dengue and chikungunya have re-emerged causing local, sporadic outbreaks ignited by travel-imported cases. The recent Zika virus outbreak in the ...
Drug design strategies against newly emerging viral diseases KU Leuven
The proposed project aims at the structure-based design of novel selective inhibitors for the treatment of specific vector-borne diseases mainly parasitic (schistosomiasis, human African trypanosomiasis, leishmaniasis, Chagas disease) and viral hemorrhagic fevers. It will be a challenging task to find those compounds that have maximal efficacy against the intruder, but minimal toxicity for the host as the differences between few parasitic target ...
The zebrafish as an emerging model to study DNA damage in aging, cancer and other diseases Ghent University
Cancer is a disease of the elderly, and old age is its largest risk factor. With age, DNA damage accumulates continuously, increasing the chance of malignant transformation. The zebrafish has emerged as an important vertebrate model to study these processes. Key mechanisms such as DNA damage responses and cellular senescence can be studied in zebrafish throughout its life course. In addition, the zebrafish is becoming an important resource to ...