The impact of biofilm architecture on the evolution of antimicrobial resistance: a single cell modelling and experimental approach KU Leuven
The rapid increase in antimicrobial resistance (AMR) forms one of the largest threats to healthcare globally. Although microbes commonly reside within dense surface associated communities called biofilms, the development of AMR has so far mainly been studied in cultures of free-living microbes. We therefore aim to study the impact of one of hallmarks of biofilms, i.e. their three dimensional architecture, on the spread of antimicrobial ...