Regulation of Self−Renewal, differentiation and Reprogramming through Wnt/B-catenin and the Tcf/Lef factors. KU Leuven
Activation of Wnt signaling can drive embryonic stem cells into opposite directions: self−renewal or ESCs differentiation. Futhermore we have demonstrated that a tuned regulation of the pathway also increase somatic cell reprogramming. How activation of the same Wnt/β−catenin signal yields disparate effects in different cell types, remains poorly understood. I hypothesize that the difference lies in the downstream effectors of the ...