Projects
Urinary incontinence and erectile dysfunction after radical prostatectomy: longitudinal evolution and the effect of intensive treatment for erectile dysfunction minimum one year after surgery. KU Leuven
Innovative therapies for pelvic floor dysfunction KU Leuven
Current clinical practice forces us to think and explore new treatment options for both urinary incontinence and pelvic organ prolapse. This project will focus on: 1. The implementation of novel treatment options for pelvic floor dysfunction: vaginal laser treatment for prolapse and urinary incontinence and the cesa-vasa surgical technique for both prolapse and urinary incontinence) 2. Optimization of laparoscopic sacrocolpopexy (current ...
Assessment of mitochondrial dysfunction at the basis of α-spectrinopathies. University of Antwerp
Understanding the relation between different disease mechanisms leading to motor neuron dysfunction in ALS Flanders Institute for Biotechnology
Autonomic dysfunction in recalcitrant functional dysphonia Ghent University
To date, patients with recalcitrant functional dysphonia (FD) have been examined and treated symptomatically (i.e. the voice itself). Due to a lack of efficacy of conventional voice therapy for this population, the significant QoL impact, and high financial burden for the healthcare system and society, research should urgently focus on the underlying pathogenesis and psychophysiological aspects related to FD and transfer these findings to ...
Exploring Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease (COPD) and Developing Biomarkers for Targeted Interventions: A Two-Part Investigation. KU Leuven
Skeletal muscle dysfunction is an important problem in individuals with Chronic Obstructive Pulmonary Disease (COPD). The dysfunction is not directly related to the impairment in lung function, but is nevertheless severely disabling patients. The main factors contributing to its development are not well understood. Furthermore it is unclear whether the presence of more pronounced skeletal muscle dysfunction may favor specific treatment ...
Deciphering the molecular mechanism that account for intestinal barrier dysfunction in cirrhosis KU Leuven
Cirrhosis is the end result of chronic liver diseases and its pathophysiology is paired with a progressive breach of the intestinal barrier. In my research proposal, I shall address the fundamental question on how the intestinal barrier fails in cirrhosis. In the lab wel apply single-cell RNAsequencing to survey the transcriptional landscape of epithelial and immune cells from control and cirrhosis patients to map cellular and molecular ...
Metabolic dysfunction of skeletal cells during osteoporotic bone loss KU Leuven
In vivo PET of synaptic density in cognitive disorders: prospective evaluation of neuronal dysfunction and relation to symptomatology. KU Leuven
Currently, 18F-FDG PET is used for differential diagnosis in patients with cognitive dysfunction. It has the disadvantage that regional glucose metabolism is a combination of neuronal and astrocytic activity as well as neuroinflammation, which may mask true changes in synaptic activity. Imaging of SV2A serves as a proxy of synaptic density. This study will investigate and compare the diagnostic accuracy of 18F-SynVesT-1 to 18F-FDG PET in ...