Projects
Technical Assistance to the second nationwide Tuberculosis Drug Resistance Survey in Bangladesh from 2018 to 2019 Institute of Tropical Medicine
Experimental evolution in Candida biofilms: does drug tolerance facilitate drug resistance development in fungi?Experimental evolution in Candida biofilms: does drug tolerance facilitate drug resistance development in fungi? KU Leuven
Invasive fungal infections pose a profound and growing public health threat with treatment failure and mortality estimates often surpassing 50%. Only three major antifungal drug classes are available to treat lethal fungemia and the incidence of resistance to these drugs has risen significantly in recent years. Moreover, multidrug resistant (MDR) ‘superbugs’ like Candida auris have emerged. Despite these alarming concerns, fungal infections ...
Drug resistance in MYC/MYCN driven tumor entities as a consequence of replicative stress induced DNA damage response: an entry point for synthetic lethal drugs Ghent University
Chemoresistance is a major impediment to succesful treatment of a growing number of cancer entitites. Circumventing this phenomenon demands highly selective and efficient targeting of cancer-specific pathways. We have recently discovered that MYC(N)-driven tumors show strong upregulation of genes involved in replicative stress-induced DNA damage repair. We thereby identified FOXM 1 as a central regulator. Our data suggest that FOXM1 driven ...
Drug resistance in MYC/MYCN driven tumor entities as a consequence of replicative stress induced DNA damage response : an entry point for synthetic lethal drugs. University of Antwerp
Identification of drug resistance mechanisms and acquired sensitivities in resistant cancer cells using genome-wide CRISPR-mediated screens KU Leuven
Multidrug resistance is a major issue in the cancer field. To counter this problem, extensive research unravelling the molecular mechanisms underlying multidrug resistance is highly needed. This enables the discovery of biomarkers and facilitates the identification of novel drug targets. For this purpose, genome-wide CRISPR screens, based on gene activation and gene knock-out, will be implemented. In this way, resistance mechanisms to ...
Trends in fluoroquinolone resistance in new TB patients in Bangladesh and the subsequent rate of acquired drug resistance Institute of Tropical Medicine
The secondary objective is to assess whether patients with baseline FQ resistance without baseline rifampicin resistance experience higher rates of failure due to acquired resistance to non-FQ TB drugs (including ...
Experimental induction of miltefosine resistance in intracellular Leishmania donovani and L. infantum amastigotes to study the influence of resistance on the interaction between drug, host and parasite University of Antwerp
Identifying Genetic Correlates of HIV-1 Drug Resistance Using a Multifaceted Approach: Genotype-Treatment, Genotype-Phenotype, and Genotype-Clinical Outcome Correlations KU Leuven
HIV-1 drug-resistance knowledge is critical for antiretroviral (ARV) drug design, the management of HIV-1 infected patients, and estimating transmitted drug resistance (TDR). However, understanding the genetic basis of HIV-1 drug resistance is hindered by the high levels of naturally occurring polymorphisms and large numbers of mutation patterns associated with cross-resistance within each antiretroviral drug class.
I studied three ...