Publications

Chosen filters:
Chosen filters:

1 - 10 of 3446 results

Sorteren op
Search term:

Mechanism of antiviral drug resistance of vaccinia virus: identification of residues in the viral DNA polymerase conferring differential resistance to antipoxvirus drugs KU Leuven

Robert Snoeck, Erik De Clercq, Ghislain Opdenakker, Graciela Andrei
The acyclic nucleoside phosphonate (ANP) family of drugs shows promise as therapeutics for treating poxvirus infections. However, it has been questioned whether the utility of these compounds could be compromised through the intentional genetic modification of viral sequences by bioterrorists or the selection of drug resistance viruses during the course of antiviral therapy. To address these concerns, vaccinia virus (strain Lederle) was passaged ...

Trypanocidal drugs and the problem of drug resistance in West Africa Ghent University

Séna Hervé Vitouley
For more than half a century, livestock trypanosomosis in West Africa has been the subject of various research papers published in the scientific literature. Since the discovery of the first Trypanosoma congolense (T. congolense) resistant strain in 1984, several studies have alerted on the increasing phenomenon of trypanocidal drug resistance (TDR) in the cotton belt of West Africa against the two commonly molecules used in this area i.e. ...

Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs Institute of Tropical Medicine

PE Almeida da Silva, JC Palomino
Tuberculosis (TB) remains one of the leading public health problems worldwide. Declared as a global emergency in 1993 by the WHO, its control is hampered by the emergence of multidrug resistance (MDR), defined as resistance to at least rifampicin and isoniazid, two key drugs in the treatment of the disease. More recently, severe forms of drug resistance such as extensively drug-resistant (XDR) TB have been described. After the discovery of ...

Exploiting knowledge on Leishmania drug resistance to support the quest for new drugs Institute of Tropical Medicine University of Antwerp

Aya Emad HEFNAWY, Maya Berg, JC Dujardin, Géraldine De Muylder

New drugs are needed to control leishmaniasis and efforts are currently ongoing to counter the neglect of this disease. We discuss here the utility and the impact of associating drug resistance (DR) studies to drug discovery pipelines. We use as paradigm currently used drugs, antimonials and miltefosine, and complement our reflection by interviewing three experts in the field. We suggest DR studies to be involved at two different stages of ...

Prevalence of pyrazinamide resistance across the spectrum of drug resistant phenotypes of Mycobacterium tuberculosis University of Antwerp

Michael G. Whitfield, Elizabeth M. Streicher, Tania Dolby, John A. Simpson, Samantha L. Sampson, Paul D. Van Helden, Annelies Van Rie, Robin M. Warren
Pyrazinamide resistance is largely unknown in the spectrum of drug resistant phenotypes. We summarize data on PZA resistance in clinical isolates from South Africa. PZA DST should be performed when considering its inclusion in treatment of patients with rifampicin-resistant TB or MDR-TB. (C) 2016 Elsevier Ltd. All rights reserved.

High prevalence of drug resistance in animal trypanosomes without a history of drug exposure Institute of Tropical Medicine

Simbarashe Chitanga, T Marcotty, B. Namangala, Peter Van den Bossche, Jan Van Den Abbeele, V Delespaux
BACKGROUND: Trypanosomosis caused by Trypanosoma congolense is a major constraint to animal health in sub-Saharan Africa. Unfortunately, the treatment of the disease is impaired by the spread of drug resistance. Resistance to diminazene aceturate (DA) in T. congolense is linked to a mutation modifying the functioning of a P2-type purine-transporter responsible for the uptake of the drug. Our objective was to verify if the mutation was linked or ...