Performance of supersaturating drug delivery systems in real-life conditions: in vivo characterisation of gastric drug behavior supporting the development of predictive tools. KU Leuven
Once marketed, drugs may suffer from suboptimal performance as they are often taken with meals and/or beverages not accounted for during clinical trials. Any ingested formulation will initially reside in the stomach where exposure to a variety of internal (e.g. pH and motility) and external factors (e.g. co-administration of beverages and foods) potentially influences intragastric formulation disintegration and drug dissolution. As this ...