Publications
Moderate-to-severe diarrhea and stunting among children younger than 5 years: findings from the Vaccine Impact on Diarrhea in Africa (VIDA) Study Institute of Tropical Medicine
BACKGROUND: Stunting affects >20% of children <5 years old worldwide and disproportionately impacts underserved communities. The Vaccine Impact on Diarrhea in Africa (VIDA) Study examined the association between an episode of moderate-to-severe diarrhea (MSD) and the risk of subsequent stunting in children <5 years living in 3 sub-Saharan African countries.
METHODS: In this prospective, matched, case-control study among ...
Antibiotic-prescribing practices for management of childhood diarrhea in 3 sub-Saharan African countries: findings from the Vaccine Impact on Diarrhea in Africa (VIDA) Study, 2015-2018 Institute of Tropical Medicine
BACKGROUND: Despite antibiotic prescription being recommended for dysentery and suspected cholera only, diarrhea still triggers unwarranted antibiotic prescription. We evaluated antibiotic-prescribing practices and their predictors among children aged 2-59 months in the Vaccine Impact on Diarrhea in Africa (VIDA) Study performed in The Gambia, Mali, and Kenya.
METHODS: VIDA was a prospective case-control study (May 2015-July 2018) ...
Exploring survey-based water, sanitation, and animal associations with enteric pathogen carriage: comparing results in a cohort of cases with moderate-to-severe diarrhea to those in controls in the Vaccine Impact on Diarrhea in Africa (VIDA) Study, 2015-2 Institute of Tropical Medicine
BACKGROUND: The magnitude of pediatric enteric pathogen exposures in low-income settings necessitates substantive water and sanitation interventions, including animal feces management. We assessed associations between pediatric enteric pathogen detection and survey-based water, sanitation, and animal characteristics within the Vaccine Impact on Diarrhea in Africa case-control study.
METHODS: In The Gambia, Kenya, and Mali, we assessed ...
Survey-based assessment of water, sanitation, and animal-associated risk factors for moderate-to-severe diarrhea in the Vaccine Impact on Diarrhea in Africa (VIDA) Study: The Gambia, Mali, and Kenya, 2015-2018 Institute of Tropical Medicine
BACKGROUND: Pediatric exposures to unsafe sources of water, unsafely managed sanitation, and animals are prevalent in low- and middle-income countries. In the Vaccine Impact on Diarrhea in Africa case-control study, we examined associations between these risk factors and moderate-to-severe diarrhea (MSD) in children <5 years old in The Gambia, Kenya, and Mali.
METHODS: We enrolled children <5 years old seeking care for MSD at ...
Lactobacillus reuteri DSM 17938 shortens acute infectious diarrhea in a pediatric outpatient setting Vrije Universiteit Brussel
OBJECTIVE: Two randomized controlled clinical trials have shown that Lactobacillus (L) reuteri DSM 17938 reduces the duration of diarrhea in children hospitalized due to acute infectious diarrhea. This was the first trial evaluating the efficacy of L. reuteri DSM 17938 in outpatient children with acute infectious diarrhea.
METHODS: This was a multicenter, randomized, single-blinded, case control clinical trial in children with acute ...
Intestinal parasites in children up to 14 years old hospitalized with diarrhea in Mozambique, 2014-2019 Institute of Tropical Medicine
Burden and epidemiology of rotavirus diarrhea in selected African countries: preliminary results from the African Rotavirus Surveillance Network Institute of Tropical Medicine
Severe rotavirus diarrhea in children <5 years of age is a major public health problem; however, limited regional and country specific data on rotavirus disease burden are available from sub-Saharan Africa. In June 2006, the World Health Organization Regional Office for Africa initiated rotavirus surveillance in selected African countries. With use of standardized methodology developed by the World Health Organization, children <5 years ...
Lactobacillus reuteri DSM 17938 effectively reduces the duration of acute diarrhea in hospitalized children Vrije Universiteit Brussel
Guidelines consider certain probiotics useful in the management of acute gastroenteritis. This study evaluated the use of Lactobacillus (L) reuteri DSM 17938.
METHODS:
A multicentre, randomised, single-blind clinical trial was performed in hospitalised children with acute gastroenteritis lasting 12-72 h. Children received conventional therapy with, or without, 1 × 10(8) CFU of L. reuteri DSM 17938 for 5 ...