Publications
Chosen filters:
Chosen filters:
Penile application of dextrin sulphate gel (Emmelle) Institute of Tropical Medicine
Unique gene expression and MR T-2 relaxometry patterns define chronic murine dextran sodium sulphate colitis as a model for connective tissue changes in human Crohn's disease Ghent University KU Leuven
Introduction: Chronically relapsing inflammation, tissue remodeling and fibrosis are hallmarks of inflammatory bowel diseases. The aim of this study was to investigate changes in connective tissue in a chronic murine model resulting from repeated cycles of dextran sodium sulphate (DSS) ingestion, to mimic the relapsing nature of the human disease. Materials and Methods: C57BL/6 mice were exposed to DSS in drinking water for 1 week, followed by ...
Dextran sulfate triggers platelet aggregation via direct activation of PEAR1 KU Leuven
Dextran sulfate (DxS; Mr 500 kD) induces fibrinogen receptor (αIIbβ3) activation via CLEC-2/Syk signaling and via a Syk-independent SFK/PI3K/Akt-dependent tyrosine kinase pathway in human and murine platelets. The platelet surface receptor, responsible for the DxS-induced Syk-independent Akt-activation, has hitherto not been identified. We found that DxS elicited a concentration-dependent aggregation of human platelets resulting from direct ...
Structural studies on the interaction of lysozyme with dextran sulfate KU Leuven
The complexation between hen egg white lysozyme (Lys) and high molecular weight dextran sulfate sodium salt (DSS) was investigated by means of dynamic light scattering (DLS), phase analysis, optical microscopy and UV–vis absorption measurements at different pH and univalent electrolyte concentrations. The specific pH values where soluble complex formation is initiated (pHc) and where phase separation occurs (pHϕ) were strongly dependent on the ...
Intrarectal nitric oxide administration prevents cellular infiltration but not colonic injury during dextran sodium sulfate colitis Ghent University
The damaged mucosal barrier in intestinal inflammation: interaction with therapeutic bacteria and roles for metallothioneins as immunomodulators Ghent University
De ziekte van Crohn en colitis ulcerosa zijn de belangrijkste chronische ontstekingsziekten van de darm. Recente studies benadrukken het belang van schade aan de epitheelbarrière en defecten in het aangeboren immuunsysteem in het ontstaan van beide ziekten. Deze schade zorgt ervoor dat de interactie tussen de microbiële darmflora en de gastheer niet meer optimaal verloopt. Het darmepitheel dient een fysische barrière te vormen tussen het lumen ...