Projects
Integrated approach for the assessment of the anatomical traits for the prospective selection of obstructive sleep apnea patients for upper airway stimulation or its combination therapy with mandibular advancement device. University of Antwerp
Innovative imaging techniques to predict treatment outcome in pediatric obstructive sleep apnea. University of Antwerp
Determining the instructive tissue signals and the master transcription factors driving Kupffer cell differentiation Flanders Institute for Biotechnology
Role of microRNAs in the pathogenesis of obstructive airway diseases Ghent University
Genetic predisposition and the environment play a crucial role in the pathogenesis of obstructive airway diseases, such as asthma and COPD. This translational project will unravel the contribution of epigenetic changes, in particular of microRNAs, in the pathogenesis of both diseases using expression analyses, in vitro studies on human cell cultures and in vivo research on murine models of asthma en COPD.
Use of a walking assistive ankle foot exoskeleton in the rehabilitation of patients with chronic obstructive pulmonary disease to counter reduced exercise capacity Ghent University
Ghent’s University lab was the first ever to reduce metabolic energy cost with an ankle assisting exoskeleton below the cost of walking with normal shoes. The aim of this doctoral research is to optimize exoskeletal assistance to improve walking capacity of patients with COPD by reducing metabolic cost and to implement the exoskeleton in the rehabilitation of COPD patients
A central role for the mesothelium in Restrictive Allograft Syndrome after lung transplantation KU Leuven
Chronic lung allograft dysfunction (CLAD) remains the major long term complication after lung transplantation. Recently, a new clinical phenotype, restrictive allograft syndrome (RAS), is identified which affects 30% of CLAD patients and which results in a survival after diagnosis limited to 0.5-1 year. In this project, we hypothesize an important role for mesothelial cells and mesothelial mesenchymal transition (MMT) in RAS. Our aim is to ...
Innovative pathophysiological phenotyping of obstructive sleep apnea patients for individualized therapy selection. University of Antwerp
Multimodal Signal Analysis for Unobtrusive Characterization of Obstructive Sleep Apnea KU Leuven
Obstructive sleep apnea (OSA) is the most prevalent sleep related breathing disorder, nevertheless subjects suffering from it often remain undiagnosed due to the cumbersome diagnosis procedure. Moreover, the prevalence of OSA is increasing and a better phenotyping of patients is needed in order to prioritize treatment. The goal of this thesis was to tackle those challenges in OSA diagnosis, by means of advanced signal processing algorithms, ...
Multimodal signal analysis for unobtrusive characterization of obstructive sleep apnea. KU Leuven
To develop a reliable sleeping platform that is suitable for the home environment.