Publications
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Intraneuronal and intercellular drivers of successful axonal regeneration in adult zebrafish -Unraveling the role of mitochondrial dynamics and Müller glia-myeloid cell crosstalk in optic nerve regeneration- KU Leuven
Treating ischemic and traumatic central nervous system (CNS) insults as well as neurodegenerative disorders like Alzheimer's and Parkinson's disease, multiple sclerosis and glaucoma, is one of the leading medical and socioeconomic challenges faced by our aging society. These currently incurable conditions lead to progressive neuronal degeneration and irreversible impairments in the adult mammalian CNS, as damaged neurons cannot be repaired, ...
Pancreatic beta-cells: From generation to regeneration. Vrije Universiteit Brussel
The pancreas is composed of two main compartments consisting of endocrine and exocrine tissues. The majority of the organ is exocrine and responsible for the synthesis of digestive enzymes and for their transport via an intricate ductal system into the duodenum. The endocrine tissue represents less than 2% of the organ and is organized into functional units called islets of Langerhans, comprising alpha-, beta-, delta-, epsilon- and PP-cells, ...
Assessing network degeneration and phenotypic heterogeneity in genetic frontotemporal lobar degeneration by decoding FDG-PET University of Antwerp Flanders Institute for Biotechnology
Genetic mutations causative of frontotemporal lobar degeneration (FTLD) are highly predictive of a specific proteinopathy, but there exists substantial inter-individual variability in their patterns of network degeneration and clinical manifestations. We collected clinical and 18Fluorodeoxyglucose-positron emission tomography (FDG-PET) data from 39 patients with genetic FTLD, including 11 carrying the C9orf72 hexanucleotide expansion, 16 ...
IL-33trap-mediated IL-33 neutralization does not exacerbate choroidal neovascularization, but fails to protect against retinal degeneration in a dry age-related macular degeneration model. Flanders Institute for Biotechnology KU Leuven Ghent University
Predictors of shoulder degeneration in the KwaZulu-Natal population of South Africa Ghent University
Evidence for the role of placental growth factor inhibition in the treatment of age-related macular degeneration KU Leuven
Angiogenese of het proces van nieuwe bloedvatvorming is de belangrijkste complicatie van leeftijdsgebonden macula degeneratie (SMD); hetgeen de belangrijkste oorzaak is van blindheid in de ontwikkelde wereld. In de laatste decennia werd alle aandacht gericht op het verhinderen van de werking van VEGF, een onontbeerlijke hoofdrolspeler in angiogenese. Dit heeft geleid tot de ontwikkeling van anti-VEGF antistoffen zoals Lucentis, Avastin en ...
Corticospinal tract degeneration associated with TDP-43 type C pathology and semantic dementia University of Antwerp
Four subtypes of frontotemporal lobar degeneration with TDP-43 immunoreactive inclusions have been described (types A-D). Of these four subtypes, motor neuron disease is more commonly associated with type B pathology, but has also been reported with type A pathology. We have noted, however, the unusual occurrence of cases of type C pathology having corticospinal tract degeneration. We aimed to assess the severity of corticospinal tract ...
The role of mutant TAR DNA-binding protein 43 in amyotrophic lateral sclerosis and frontotemporal lobar degeneration University of Antwerp
TDP-43 (TAR DNA-binding protein 43) has been identified as a key protein of ubiquitinated inclusions in brains of patients with ALS (amyotrophic lateral sclerosis) or FTLD (frontotemporal lobar degeneration), defining a new pathological disease spectrum. Recently, coding mutations have been identified in the TDP-43 gene (TARDBP), which further confirmed the pathogenic nature of the protein. Today, several animal models have been generated to ...
Qualitative and quantitative assessment of degeneration of cervical intervertebral discs and facet joints KU Leuven
Degeneration of intervertebral discs and facet joints is one of the most frequently encountered spinal disorders. In order to describe and quantify degeneration and evaluate a possible relationship between degeneration and biomechanical parameters, e.g., the intervertebral range of motion and intradiscal pressure, a scoring system for degeneration is mandatory. However, few scoring systems for the assessment of degeneration of the cervical spine ...