Publications
Antiviral drug-resistance typing reveals compartmentalization and dynamics of acyclovir-resistant herpes simplex virus type-2 (HSV-2) in a case of neonatal herpes KU Leuven
Shifts in mycobacterial populations and emerging drug-resistance in west and central Africa Institute of Tropical Medicine University of Antwerp
In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and modern mycobacterial lineages, we conducted phenotypic drug-susceptibility-testing for each isolate for the four first-line drugs. We showed that phylogenetically modern Mycobacterium ...
Mitigating the threat of artemisinin resistance in Africa: improvement of drug-resistance surveillance and response systems Institute of Tropical Medicine
HIV-1 drug-resistance patterns among patients on failing treatment in a large number of European countries KU Leuven
HIV-1 drug-resistance patterns among patients on failing treatment in a large number of European countries University of Antwerp
Molecular surveillance of drug-resistance associated mutations of Plasmodium falciparum in south-west Tanzania Institute of Tropical Medicine
Background: In Tanzania, drug-resistant malaria parasites are an increasing public health concern. Because of widespread chloroquine (CQ) resistance Tanzania changed its first line treatment recommendations for uncomplicated malaria from CQ to sulfadoxine-pyrimethamine (SP) in 2001. Loss of SP sensitivity is progressing rapidly. SP resistance is associated with mutations in the dihydrofolate reductase (pfdhfr) and dihydropteroate synthase ...
A Case Report of Multiclass HIV Drug-Resistance After an Inappropriate Switch of ARVs with Persistent Unsuppressed Viral Load KU Leuven
The emerging threat of pre-extensively drug-resistant tuberculosis in West Africa: preparing for large-scale tuberculosis research and drug resistance surveillance Institute of Tropical Medicine
Background: Drug-resistant tuberculosis (TB) is a global public health problem. Adequate management requires baseline drug-resistance prevalence data. In West Africa, due to a poor laboratory infrastructure and inadequate capacity, such data are scarce. Therefore, the true extent of drug-resistant TB was hitherto undetermined. In 2008, a new research network, the West African Network of Excellence for Tuberculosis, AIDS and Malaria (WANETAM), ...