Projects
OrBITS Platform: A Cloud-Based Image Analysis and Drug Screening Service. University of Antwerp
A combination of Live Mouse Tracker (LMT) and Multi-Electrode Array (MEA) as a versatile drug screening platform for fragile X syndrome. University of Antwerp
New machine-vision and automation methods for high throughput combinatorial drug screening KU Leuven
Next Generation Screening in Quantitative Biology & Drug Discovery KU Leuven
In this proposal we outline a state-of-the-art platform that would be among the first in Europe to combine the best in automated microscopy with advanced cell culture robotics capable of automated isolation, expansion and differentiation of mammalian and human cells, including iPSC. The platform will be unique in Flanders and will allow running quantitative image-based screens as well as screens for disease phenotypes using conventional cell ...
Business development of a drug screening Spin-off company based on 2D & 3D human iPSC-derived liver cell models for NASH & (i)DILI. KU Leuven
Drug discovery for Parkinson’s disease using a translational screening platform KU Leuven
Development of an image-based multiparametric drug response signature to predict clinical therapy response in cancer patients from ex vivo tumoroid screenings. University of Antwerp
Experimental evolution in Candida biofilms: does drug tolerance facilitate drug resistance development in fungi?Experimental evolution in Candida biofilms: does drug tolerance facilitate drug resistance development in fungi? KU Leuven
Invasive fungal infections pose a profound and growing public health threat with treatment failure and mortality estimates often surpassing 50%. Only three major antifungal drug classes are available to treat lethal fungemia and the incidence of resistance to these drugs has risen significantly in recent years. Moreover, multidrug resistant (MDR) ‘superbugs’ like Candida auris have emerged. Despite these alarming concerns, fungal infections ...