DOT1l in Osteoarthritis: The DOTOS project will study the role of DOT1L in synovial joint development, homeostasis and disease with specific attention towards osteoarthritis (OA), KU Leuven
The DOTOS project will study the role of DOT1L in synovial joint development, homeostasis and disease with specific attention towards osteoarthritis (OA), one of the most common chronic diseases.
We identified an association between the DOT1L (DOT1-like histone H3 methyltransferase) gene and OA. Histone methylation is a regulator of gene transcription. Some histone methylations result in increased gene expression, e.g. lysine ...