The role of DOT1L in systemic sclerosis KU Leuven
Systemic sclerosis is a devastating connective tissue disease with high morbidity and mortality. The pathophysiology is marked by autoimmunity, vascular changes and fibrosis of skin and internal organs. The complex interplay between various pathways in the pathogenesis is still incompletely understood. Two involved mechanisms are the activation of the canonical Wingless-type like (Wnt) signaling, and an imbalance in oxidative state leading to ...