Publications
Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals Ghent University
The role of methylation, DNA polymorphisms and microRNAs on HLA-G expression in human embryonic stem cells Vrije Universiteit Brussel
The human leukocyte antigen (HLA)-G gene seems to play a pivotal role in maternal tolerance to the fetus. Little is known about HLA-G expression and its molecular control during in vivo human embryogenesis. Human embryonic stem cells (hESC) provide an interesting in vitro model to study early human development. Different studies reported discrepant findings on whether HLA-G mRNA and protein are present or absent in hESC. Several lines of ...
Strategies for validation and testing of DNA methylation biomarkers Ghent University
Technical considerations in PCR-based assay design for diagnostic DNA methylation cancer biomarkers Ghent University
RDM16 and STA1 regulate differential usage of exon/intron in RNA directed DNA methylation pathway Ghent University KU Leuven
Occurrence of DNA methylation in Daphnia magna and influence of multigeneration Cd exposure Research Institute for Agriculture, Fisheries and Food Ghent University
Temporal variability of global DNA methylation and hydroxymethylation in buccal cells of healthy adults: Association with air pollution Hasselt University KU Leuven
Promoter DNA methylation regulates progranulin expression and is altered in FTLD Vrije Universiteit Brussel University of Antwerp
BACKGROUND: Frontotemporal lobar degeneration (FTLD) is a heterogeneous group of neurodegenerative diseases associated with personality changes and progressive dementia. Loss-of-function mutations in the growth factor progranulin (GRN) cause autosomal dominant FTLD, but so far the pathomechanism of sporadic FTLD is unclear.
RESULTS: We analyzed whether DNA methylation in the GRN core promoter restricts GRN expression and, thus, might ...
Genome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT-ROBO, ITGA2 and MET signaling Vrije Universiteit Brussel
The importance of epigenetic modifications such as DNA methylation in tumorigenesis is increasingly being appreciated. To define the genome-wide pattern of DNA methylation in pancreatic ductal adenocarcinomas (PDAC), we captured the methylation profiles of 167 untreated resected PDACs and compared them to a panel of 29 adjacent nontransformed pancreata using high-density arrays. A total of 11,634 CpG sites associated with 3,522 genes were ...