Genome-wide methylation analysis unravels differential DNA methylation patterns between (prognostic) neuroblastoma patient subgroups Ghent University
Neuroblastoma (NB) has been considered as a disease driven by genetic aberrations. However, recent studies have shown that the NB biology is also strongly determined by the epigenetic profile of the tumor, an important finding underscored by the fact that whole-genome sequencing of primary NB tumors revealed no highly recurrent mutations, apart from activating ALK mutations. By profiling the methylome of more than 100 primary NB tumors using ...