Publications
Soluble CD26 / dipeptidyl peptidase IV enhances human lymphocyte proliferation **in vitro** independent of dipeptidyl peptidase enzyme activity and adenosine deaminase binding University of Antwerp
Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9: part 2: isoindoline constaining inhibitors University of Antwerp
Acute Ischemic Stroke Severity, Progression, and Outcome Relate to Changes in Dipeptidyl Peptidase IV and Fibroblast Activation Protein Activity Vrije Universiteit Brussel University of Antwerp
Dipeptidyl peptidase IV (DPPIV) inhibition may be a promising therapeutic strategy for acute stroke treatment, given its potential to prolong the biological half-life of neuroprotective substrates. A related protease, fibroblast activation protein (FAP), was recently shown to inactivate the same substrates. Therefore, it should also be investigated as a potential target in stroke. The study aimed to investigate whether stroke severity and ...
Application of the dipeptidyl peptidase IV (DPPIV/CD26) based prodrug approach to different amine-containing drugs KU Leuven University of Antwerp
Dipeptidyl Peptidase IV (DPPIV/CD26)-Based Prodrugs of Hydroxy-Containing Drugs KU Leuven University of Antwerp
The dipeptidyl peptidase family, prolyl oligopeptidase, and prolyl carboxypeptidase in the immune system and inflammatory disease, including atherosclerosis University of Antwerp
Dipeptidyl peptidase IV-activated prodrugs of anti-varicella zoster virus bicyclic nucleoside analogues containing different self-cleavage spacer systems KU Leuven University of Antwerp
Regulation of Chemokine Activity - A Focus on the Role of Dipeptidyl Peptidase IV/CD26 Vrije Universiteit Brussel KU Leuven
Chemokines are small, chemotactic proteins that play a crucial role in leukocyte migration and are, therefore, essential for proper functioning of the immune system. Chemokines exert their chemotactic effect by activation of chemokine receptors, which are G protein-coupled receptors (GPCRs), and interaction with glycosaminoglycans (GAGs). Furthermore, the exact chemokine function is modulated at the level of posttranslational modifications. ...